April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Pathology and Management of Orbital Cysts seen in Microphthalmos
Author Affiliations & Notes
  • Sean Paul
    Ophthalmology, Dean McGee Eye Institute, University of Oklahoma, Oklahoma City, Oklahoma
  • Leslie Wei
    Ophthalmology, University of Colorado Denver, Denver, Colorado
  • Amy Kulak
    Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York
  • Paul D. Langer
    Dept of Ophthalmology, New Jersey Med School, Newark, New Jersey
  • John Shore
    Texas Oculoplastic Consultants, Austin, Texas
  • Dan S. Gombos
    Section of Ophthalmology, Univ Texas MD Anderson Cancer Ctr, Houston, Texas
  • Vikram Durairaj
    Ophthalmology, University of Colorado Denver, Denver, Colorado
  • Roman Shinder
    Ophthalmology, SUNY Downstate Medical Center, Brooklyn, New York
  • Footnotes
    Commercial Relationships  Sean Paul, None; Leslie Wei, None; Amy Kulak, None; Paul D. Langer, None; John Shore, None; Dan S. Gombos, None; Vikram Durairaj, None; Roman Shinder, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 732. doi:
  • Views
  • Share
  • Tools
    • Alerts
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Sean Paul, Leslie Wei, Amy Kulak, Paul D. Langer, John Shore, Dan S. Gombos, Vikram Durairaj, Roman Shinder; Pathology and Management of Orbital Cysts seen in Microphthalmos. Invest. Ophthalmol. Vis. Sci. 2011;52(14):732.

      Download citation file:

      © ARVO (1962-2015); The Authors (2016-present)

  • Supplements

Microphthalmos with orbital cyst (MOC) represents a rare colobomatous disorder due to failure of invagination of the optic vesicle in the early gestational period. We report the presentation, radiography, histology, and treatment outcomes in 5 patients with MOC.


Records of 5 patients evaluated for MOC were reviewed.


4 patients were male and 1 female with a median age of 8.3 years (range 2 months - 40 years). 4 patients presented with original disease, while 1 patient had recurrence after cyst drainage at an outside institution. The diagnosis in all patients was confirmed by exam, orbital CT/MRI/US, and histologic evaluation following orbitotomy and surgical excision in all cases except one lost to follow-up (Fig 1, 2). Reconstruction of the resultant anophthalmic socket included dermis fat grafting in children and alloplastic orbital implant in adults.


MOC is a rare childhood diagnosis with a mean age at presentation of 5.4 years. Orbital imaging through CT or MRI is crucial to establish the diagnosis. The treatment depends on the severity of presentation, and ranges from observation or fitting with a cosmetic scleral shell for mild cases, to enucleation with cyst excision and orbital reconstruction in more severe cases. Reconstruction of the anophthalmic socket in children should attempt to maximize orbital volume either with a dermis fat graft or largest orbital implant that can safely be positioned without risk of extrusion. Cyst drainage should not be a definitive treatment and may lead to recurrence of ocular signs and symptoms as was the case in one of our patients.  

Keywords: orbit • development • pathology: human 

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.