April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Comparative Cost-effectiveness Analysis Of Descemet Stripping Endothelial Keratoplasty Versus Penetrating Keratoplasty
Author Affiliations & Notes
  • Shreya S. Patel
    Ophthalmology,
    University of Michigan, Ann Arbor, Michigan
  • Rola Kaakeh
    University of Michigan, Ann Arbor, Michigan
  • Dean G. Smith
    University of Michigan, Ann Arbor, Michigan
  • Roni M. Shtein
    Ophthalmology,
    University of Michigan, Ann Arbor, Michigan
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 761. doi:
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      Shreya S. Patel, Rola Kaakeh, Dean G. Smith, Roni M. Shtein; Comparative Cost-effectiveness Analysis Of Descemet Stripping Endothelial Keratoplasty Versus Penetrating Keratoplasty. Invest. Ophthalmol. Vis. Sci. 2011;52(14):761.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To perform a comparative cost-effectiveness analysis of Descemet stripping endothelial keratoplasty (DSEK) and penetrating keratoplasty (PKP) for corneal endothelial disease.

Methods: : This cost-effectiveness analysis was performed from a third party payor perspective over a 5-year period. A model was constructed to compare the costs and utilities associated with DSEK and PKP. Probabilities of outcomes and complications of each of the procedures were calculated based on systematic review of the published literature. Costs of donor tissue preparation, surgery, follow-up, post-operative complications and procedures were considered. Utility values were based on visual acuity outcomes. Sensitivity analyses were performed with two-way analyses of cost, graft failure rates, and glaucoma rates.

Results: : DSEK and PKP were found to be equally cost-effective with similar utilities and costs.

Conclusions: : This initial comparative cost-effectiveness analysis of DSEK vs. PKP indicates similar costs of the two procedures for treatment of corneal endothelial disease. Longer term follow-up of DSEK outcomes will provide more accurate information regarding long-term costs of the procedure.

Keywords: cornea: clinical science 
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