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Jennifer Y. Li, Mark A. Terry, Jeff Goshe, David L. Davis-Boozer; Longer-Term Endothelial Cell Loss After Descemet's Stripping Endothelial Keratoplasty In A Large Prospective Series. Invest. Ophthalmol. Vis. Sci. 2011;52(14):768.
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To report longer-term endothelial cell loss in patients undergoing Descemet's stripping endothelial keratoplasty (DSAEK) in patients with Fuchs' endothelial dystrophy.
This is a prospective, noncomparative, interventional case series of 439 eyes undergoing DSAEK surgery for Fuchs' endothelial dystrophy. Postoperative donor endothelial cell density (ECD) at 6 months (n=439), 12 months (n=360), 2 years (n=230), 3 years (n=115), and 4 years (n=36) were recorded and compared with preoperative eye bank measurements.
The average and standard deviation percentage ECD loss at 6 months (n=439) was 24.9+/-16.1%, at 12 months (n=360) 25.0+/-16.1%, at 2 years (n=230) 25.7+/-16.6%, at 3 years (n=115) 32.4+/-18.8%, and at 4 years (n=36) 40.2+/-21.7%.
The average endothelial cell loss following DSAEK surgery in Fuchs' endothelial dystrophy patients remains relatively stable up to 2 years postoperatively. There is a subsequent gradual decline in ECD after 2 years which is observed at least through postoperative year 4.
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