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Aaron C. Enten, Derek Nankivil, Bianca Maceo, Esdras Arrieta, Fabrice Manns, Jean-Marie Parel; Optomechanical Response of Primate Lenses: Effects of Decentration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):816.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the effects of decentration on thickness, diameter, radius of curvature, and power measurements during lens stretching.
6 post-mortem (16.3 ± 12.7 hours) eyes from 3 Cynomolgus monkeys (6.7 ± 0.5 years old) were dissected leaving intact the lens, zonules, ciliary body, and hyaloid membrane. The lens preparation was mounted and aligned in an optomechanical lens stretching system (Ehrmann et al, Clin Exp Opt, 2008) and the globe was stretched 2.5mm radially in 0.25mm increments. Load, lens diameter, and lens power were measured every 0.25mm. Lens thickness and anterior and posterior radius of curvature were measured every 0.5mm using Optical Coherence Tomography (OCT) (Uhlhorn el al, Vis Res, 2008). The experiment was repeated on each eye with a manual realignment step after every measurement, and OCT doubled to record every 0.25mm.
There was no significant difference (p > 0.1) between the values of the realigned run and the automatic run. The average change in thickness, anterior and posterior radius of curvature, posterior window distance, power, and diameter after realignment was (0.04 ± 0.08)mm (p = 0.156), (-0.13 ± 0.22)mm (p = 0.213), (-0.03 ± 0.06)mm (p = 0.211), (-0.02 ± 0.06)mm (p = 0.342), (0.07 ± 0.09)D (p = 0.124), and (0.02 ± 0.08)mm (p = 0.538) respectively.
All realigned eyes showed no statistical difference from automatic runs. Decentration during lens stretching results in less than 1% error in parameters measured by OCT, and manual realignment is not of sufficient precision to compensate for decentration during lens stretching.
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