April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Optomechanical Response of Primate Lenses: Effects of Decentration
Author Affiliations & Notes
  • Aaron C. Enten
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland
  • Derek Nankivil
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • Bianca Maceo
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida
  • Esdras Arrieta
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida
  • Jean-Marie Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Vision Cooperative Research Centre, Sydney, Australia
  • Footnotes
    Commercial Relationships  Aaron C. Enten, None; Derek Nankivil, None; Bianca Maceo, None; Esdras Arrieta, None; Fabrice Manns, None; Jean-Marie Parel, None
  • Footnotes
    Support  Florida Engineering Foundation (AE), NIH 2 R01 EY14225, Florida Lions Eye Bank, Australian Government CRC Program, Research to Prevent Blindness, NIH P30 EY014801, Henri and Flore Lesieur Foundation
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 816. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Aaron C. Enten, Derek Nankivil, Bianca Maceo, Esdras Arrieta, Fabrice Manns, Jean-Marie Parel; Optomechanical Response of Primate Lenses: Effects of Decentration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):816.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To determine the effects of decentration on thickness, diameter, radius of curvature, and power measurements during lens stretching.

Methods: : 6 post-mortem (16.3 ± 12.7 hours) eyes from 3 Cynomolgus monkeys (6.7 ± 0.5 years old) were dissected leaving intact the lens, zonules, ciliary body, and hyaloid membrane. The lens preparation was mounted and aligned in an optomechanical lens stretching system (Ehrmann et al, Clin Exp Opt, 2008) and the globe was stretched 2.5mm radially in 0.25mm increments. Load, lens diameter, and lens power were measured every 0.25mm. Lens thickness and anterior and posterior radius of curvature were measured every 0.5mm using Optical Coherence Tomography (OCT) (Uhlhorn el al, Vis Res, 2008). The experiment was repeated on each eye with a manual realignment step after every measurement, and OCT doubled to record every 0.25mm.

Results: : There was no significant difference (p > 0.1) between the values of the realigned run and the automatic run. The average change in thickness, anterior and posterior radius of curvature, posterior window distance, power, and diameter after realignment was (0.04 ± 0.08)mm (p = 0.156), (-0.13 ± 0.22)mm (p = 0.213), (-0.03 ± 0.06)mm (p = 0.211), (-0.02 ± 0.06)mm (p = 0.342), (0.07 ± 0.09)D (p = 0.124), and (0.02 ± 0.08)mm (p = 0.538) respectively.

Conclusions: : All realigned eyes showed no statistical difference from automatic runs. Decentration during lens stretching results in less than 1% error in parameters measured by OCT, and manual realignment is not of sufficient precision to compensate for decentration during lens stretching.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • accommodation 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×