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Noelle S. Matta, David I. Silbert; Effects of Atropine on the Accommodative System. Invest. Ophthalmol. Vis. Sci. 2011;52(14):830.
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We set out to determine the accommodative effects of Atropine on the visual system.
A prospective study was done on a normal eye in a 31-year-old cooperative adult. One drop of Atropine was instilled and the effect on accommodation, near visual acuity and pupil size was recorded. Accommodation was measured at 1/3 of a meter utilizing the Grand Seiko Auto Refractor. Near visual acuity was measured with the PEDIG ATS 4 near visual acuity test at a set distance of 16 inches.
Atropine caused its greatest effect to accommodation, and to pupil size, 3 hours after installation. Curiously, the greatest effect on near visual acuity was seen 27 hours after instillation at which time it dropped to 20/80. Near visual acuity had improved to 20/25 on day 4. Accommodation returned to normal 8 days after instillation and pupil size returned to normal 12 days after instillation.
One drop of Atropine affected accommodation for 8 days. Despite this, near vision returned to 20/20 by day 5. These findings may impact how Atropine is prescribed to treat amblyopia both to maximize effectiveness and minimize its impact on school performance.
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