April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Interleukin 17 (IL-17) and IL-17 Receptors in the Murine and Human Diabetic Retina
Author Affiliations & Notes
  • Alex Mammen
    Medical College of Georgia, Augusta, Georgia
  • Chaunt'e Stampley
    Medical College of Georgia, Augusta, Georgia
  • Ajay Pillai
    Medical College of Georgia, Augusta, Georgia
  • Anna Lisa Montemari
    Fondazione GB Bietti, Rome, Italy
  • Livia Di Renzo
    Experimental Medicine and Pathology, University La Sapienza, Rome, Italy
  • Francesco Facchiano
    Hematology / Oncology, Istituto Superiore Di Sanita, Rome, Italy
  • Babak Baban
    Oral Biology and Maxillofacial Pathology,
    Medical College of Georgia, Augusta, Georgia
  • Manuela Bartoli
    Medical College of Georgia, Augusta, Georgia
  • Footnotes
    Commercial Relationships  Alex Mammen, None; Chaunt'e Stampley, None; Ajay Pillai, None; Anna Lisa Montemari, None; Livia Di Renzo, None; Francesco Facchiano, None; Babak Baban, None; Manuela Bartoli, None
  • Footnotes
    Support  Vision Discovery Institute, Department of Ophthalmology, Medical College of Georgia
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 998. doi:
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      Alex Mammen, Chaunt'e Stampley, Ajay Pillai, Anna Lisa Montemari, Livia Di Renzo, Francesco Facchiano, Babak Baban, Manuela Bartoli; Interleukin 17 (IL-17) and IL-17 Receptors in the Murine and Human Diabetic Retina. Invest. Ophthalmol. Vis. Sci. 2011;52(14):998.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Interleukin 17 (IL-17), a product of Th17 lymphocytes, has been shown to play a critical role in chronic inflammatory diseases. We have previously shown that circulating (serum) levels of IL-17 are increased in diabetic patients presenting signs of retinopathy. Here we further studied the expression pattern of IL-17 and its receptors (IL17Rs) in the murine and human (post-mortem) diabetic retina.

Methods: : Immuno-histochemical and ELISA analyses were conducted to determine the expression pattern of IL17Rs and IL-17 (respectively) in the retinal tissue obtained from streptozotocin-induced diabetic mice (STZ-mouse), after 8 weeks of hyperglycemia, and from human post-mortem retinas of diabetic donors. Age-matched normoglycemic mice retinas and human post-mortem retinas from non-diabetic donors were used as normal controls.

Results: : IL-17 protein levels were increased in both the murine and human diabetic retinas as compared to age-matched normoglycemic murine retinas and human non diabetic donors. IL-17Rs were also up-regulated in both murine and human retinas as compared to normoglycemic controls. Of interest, IL-17Rs were immunolocalized in the retinal ganglion cell layer, especially at the vitreoretinal interface.

Conclusions: : The results further support the potential role of IL-17 in the pathogenesis of diabetic retinopathy and also identify the vitreoretinal surface as a possible site of action of IL-17 in the diabetic retina.

Keywords: diabetic retinopathy • inflammation • immunomodulation/immunoregulation 

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