March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Corneal Sensitivity To Selective Stimulation In Iritis Patients
Author Affiliations & Notes
  • Waldir Neira
    Ophthalmology, University of Helsinki, Helsinki, Finland
    Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Spain
  • Timo T. Tervo
    Ophthalmology, University of Helsinki, Helsinki, Finland
  • M.Carmen Acosta
    Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Spain
  • Juha M. Holopainen
    Ophthalmology, University of Helsinki, Helsinki, Finland
  • Carlos Belmonte
    Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Spain
  • Juana Gallar
    Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Spain
  • Footnotes
    Commercial Relationships  Waldir Neira, None; Timo T. Tervo, None; M.Carmen Acosta, None; Juha M. Holopainen, None; Carlos Belmonte, None; Juana Gallar, None
  • Footnotes
    Support  Evald and Hilda Nissi Foundation (WN), Finnish Eye Foundation(WN),SAF2008-00529 (JG), BFU2008-04425 and CSD2007-00023 (CB) from the Ministerio de Ciencia e Innovacion, Spain
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1790. doi:https://doi.org/
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      Waldir Neira, Timo T. Tervo, M.Carmen Acosta, Juha M. Holopainen, Carlos Belmonte, Juana Gallar; Corneal Sensitivity To Selective Stimulation In Iritis Patients. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1790. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To explore whether corneal sensitivity to mechanical, chemical and thermal stimuli is affected in iritis patients.

Methods: : Twenty eight voluntary subjects participated in the study. Acute iritis patients who attended the acute ward of the Helsinki University Eye Hospital were examined with a non-contact gas esthesiometer (Belmonte OPM, Deriva Global) to measure corneal sensitivity threshold to mechanical (air flow between 0 and 200 ml/min), chemical (0 to 80% CO2 in air, at subthreshold flow) and cold (air at subthreshold flow inducing corneal temperature changes between 0.1º and -5.9ºC) stimulation. Sensation threshold was defined as the lowest stimulus intensity of each modality evoking a conscious sensation. Schirmer 1 test was used to measure tearing rate. Data from iritis patients were compared with those of a sex- and age-matched control group.

Results: : The mean sensitivity threshold values for mechanical stimulation were not significantly different in iritis patients in comparison with controls (130±20 vs. 108±4 ml/min, n=10 and 18; p=0.29, t-test). Threshold for chemical and cold stimulation were significantly higher in iritis patients in comparison with control subjects (Chemical= 48±9% vs. 21±5% CO2; p=0.008. Cold= -4.3±0.5º vs. -0.8±0.2ºC; p<0.001). Tearing rate was significantly increased in iritis patients (45±3 vs. 31±2 mm; p<0.001).

Conclusions: : Patients with iritis exhibit a lower corneal sensitivity to chemical and cold stimuli whereas mechanical sensitivity remains unaltered. These sensory disturbances presumably reflect inflammation-induced changes in the excitability of trigeminal ganglion polymodal and cold-sensitive neurons, perhaps those that innervate both the iris and the cornea. Nevertheless, the possibility that the number of nociceptive fibers decreases consecutively to chronic inflammation cannot be excluded.

Keywords: innervation: sensation • iris • cornea: clinical science 
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