March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Corneal Sensitivity and Tear Meniscus Area after Instillation of Artificial Tears Containing Sodium Hyaluronan
Author Affiliations & Notes
  • Javier Belmonte
    Servicio de Oftalmologia, Hosp Gen Univ Alicante, Alicante, Spain
  • Rocio Serrano
    Instituto de Neurociencias, Univ Miguel Hernandez-CSIC, San Juan de Alicante, Spain
  • Waldir Neira-Zalentein
    Ophthalmology, Helsinki Univ Central Hospital, Helsinki, Finland
  • M.Carmen Acosta
    Instituto de Neurociencias, Univ Miguel Hernandez-CSIC, San Juan de Alicante, Spain
  • Carlos Belmonte
    Instituto de Neurociencias, Univ Miguel Hernandez-CSIC, San Juan de Alicante, Spain
  • Juana Gallar
    Instituto de Neurociencias, Univ Miguel Hernandez-CSIC, San Juan de Alicante, Spain
  • Footnotes
    Commercial Relationships  Javier Belmonte, None; Rocio Serrano, None; Waldir Neira-Zalentein, None; M.Carmen Acosta, None; Carlos Belmonte, None; Juana Gallar, Part of the sodium hyaluronate was kindly provided by TRB Chemedica (F)
  • Footnotes
    Support  SAF2008-00529 (JG), BFU2008-04425 and CSD2007-00023 (CB) from the Ministerio de Ciencia e Innovación, Spain
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 1791. doi:
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      Javier Belmonte, Rocio Serrano, Waldir Neira-Zalentein, M.Carmen Acosta, Carlos Belmonte, Juana Gallar; Corneal Sensitivity and Tear Meniscus Area after Instillation of Artificial Tears Containing Sodium Hyaluronan. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1791.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract
 
Purpose:
 

To measure corneal sensitivity and tear meniscus area after the application of artificial tears containing different concentrations of sodium hyaluronan (NaHA).

 
Methods:
 

In young healthy volunteers of both sexes (19-35 years), corneal sensitivity to mechanical (air at 0-200 ml/min flow), chemical (0-60%CO2 in air) and cold stimuli (air at 25º to -10ºC) was measured using a gas esthesiometer before and after NaHA application. Intensity and other psychophysical attributes of the evoked sensation were scored at the end of the stimulus, using separate 10 cm visual analogue scales. Images of the anterior segment were taken using Visante OCT (Zeiss) before and 5-30 min after the instillation of NaHA solutions (0.1, 0.18 and 0.3%, in different sessions).The area, height and angle of the superior and inferior tear meniscus were measured using Image J software. Data were compared using ANOVA.

 
Results:
 

Topical NaHA solutions reduced the irritative components of the sensation evoked by mechanical and chemical stimulation of the cornea, having stronger effects with higher NaHA concentrations, while the intensity parameter was only weakly reduced by higher NaHA concentrations. Cold sensations evoked by cooling were not modified significantly by NaHA treatment. The meniscus area was slightly increased after instillation of low NaHA concentrations while it decreased after high NaHA concentrations (Table 1).

 
Conclusions:
 

NaHA solutions decrease the irritation components of the sensation evoked by high intensity mechanical and chemical stimuli while the discrimination of stimulus intensity was only slightly affected. Compared with low concentration NaHA solutions, high concentration NaHA decreased the tear meniscus area, probably reflecting a more homogeneous distribution throughout the ocular surface. This difference may explain the efficacy of high concentration NaHA solutions in reducing corneal irritation.  

 
Keywords: innervation: sensation • cornea: tears/tear film/dry eye • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
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