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Manuel Ramirez, Denis Bravo, Everardo Hernandez-Quintela, Ramon Naranjo-Tackman; A Stromal Corneal Nerves Comparison Between Normal Vs Keratoconus Patients By Confocal Microscopy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):1812.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the stromal corneal nerves differences between normal patients and keratoconus patients.
50 eyes of 25 normal patients (group A) and 36 eyes of 44 keratoconus patients (group B) were examined with the confocal microscope (Confoscan 4, Fortune Technologies, Italy), a central scan of the total corneal thickness was taken. Corneal stromal nerves morphology and thickness were evaluated by using the Navis v. 3.5.0. Software (NIDEK, Multi-Instrument Diagnostic System, Japan). Nerve thickness was obtained from the mean between the widest and the narrowest portion of each stromal nerve.
Corneal stromal nerves were observed as irregular linear hiper-reflective structures with widest and narrowest portions in all cases. Mean corneal stromal nerves thickness in group A was 5.94 ± 1.7 range from 3.4 to 10.5 microns, mean corneal stromal nerves thickness in group B was 7.2 ± 1.9 range from 3.5 to 12.0 microns. There was a statistical significant difference (P .<0001) in stromal corneal thickness between group A and group B.
Stromal corneal nerves morphology was similar in both groups, but stromal nerves were thicker in keratoconus patients.
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