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Bernhard Baumann, Benjamin Potsaid, Martin Kraus, Jonathan J. Liu, David Huang, Joachim Hornegger, Jay S. Duker, James G. Fujimoto; Ultrahigh Speed Swept Source / Fourier Domain OCT for Retinal Blood Flow Measurement. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1250.
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Alterations of retinal blood flow play a key role in retinal diseases such as diabetic retinopathy, age-related macular degeneration or glaucoma, and there is a great interest in modalities to measure retinal perfusion. Swept source / Fourier domain OCT enables three dimensional (3D) structural imaging of the retina. Doppler OCT imaging at ultrahigh speeds allows for enhanced visualization and quantification of retinal blood flow with increased sensitivity for high flow velocities in central retinal vessels.
An ultrahigh speed swept source / Fourier domain OCT was developed based on a swept laser light source at 1050nm. The system operated at 200,000 axial scans per second, 5-10X faster than commercial OCT systems. Dense 3D OCT data sets of the optic disk region were recorded in healthy human retinas. Doppler OCT images of retinal blood flow were calculated from these OCT volumetric data sets. Total flow was measured by extracting Doppler images in the en face plane and integrating over the vessel cross sections. This algorithm does not require determination of blood vessel angles as in traditional Doppler flow and is robust to retinal alignment.
Ultrahigh speed OCT allows rapid 3D imaging of the retina. Imaging at 1050-nm wavelengths enables enhanced penetration in deep structures of the optic nerve and lamina cribrosa. The high sweep rate enables the measurement of axial flow velocities up to 50mm/s in central retinal blood vessels. 3D Doppler OCT images of retinal blood flow show branching of the retinal vasculature in the optic disk region. Absolute total blood flow measurement without requiring reconstruction of the geometry of retinal vessels is possible using novel software algorithms.
Ultrahigh speed OCT based on swept laser technology enables rapid 3D imaging of the retina and Doppler OCT. Quantitative measurement of total retinal blood flow is demonstrated, which might be beneficial for assessing pathologic changes in diseases such as glaucoma and diabetic retinopathy.
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