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Xiaoyan Peng, Yongpeng Zhang, Zhihua Li, Fenghua Chen; Hyperglycemia After Periocular Dexamethasone Injection In Diabetic Patients After Vitreo-retinal Surgery. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1263.
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To assess the hyperglycemic effect of periocular injection of different dosage of dexamethasone (2.5mg or 5mg) to the type 2 diabetic patients with anterior chamber exudative reaction after vitreoretinal surgery. The change of blood glucose (BG) level was recorded and evaluated.
20 consecutive hospitalized cases of type 2 diabetic patients with ocular inflammatory reaction after VRS were enrolled in this study, in which 10 cases were in the treatment group of 2.5mg dexamethasone, 10 cases were in the treatment group of 5mg dexamethasone, 14 cases were in the control group. We measured the level of fasting blood glucose and the BG 2 hours after each meal following periocular injection of dexamethasone and analysed the difference among the treatment groups and the control group by student’s t test.
The BG level of the 2.5mg and 5mg dexamethasone treatment groups was higher than that of the control group significantly in 24 and 48 hours respectively after injection.
Periocular injection of corticosteroids was an affecting factor on transient hyperglycemia in diabetic patients after VRS and this procedure should be performed with specific BG monitoring when used repeatedly.
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