Purchase this article with an account.
John F. Payne, Robin Ray, Julia Cleveland, Michael Lynn, Sr., Sunil K. Srivastava; Serum Insulin-Like Growth Factor-I in Diabetic Retinopathy. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1266.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
There is evidence to suggest that insulin-like growth factor I (IGF-I) may play a role in the development of diabetic retinopathy. The purpose of this study was to assess the relationship between serum insulin-like growth factor I (IGF-I) levels and diabetic retinopathy.
This is a clinic-based cross sectional study conducted at the Emory Eye Center. A total of 225 subjects were classified into four groups based on diabetes status and retinopathy findings: no diabetes (No DM; n = 99), diabetes with no background diabetic retinopathy (No BDR; n = 42), nonproliferative diabetic retinopathy (NPDR; n = 41), and proliferative diabetic retinopathy (PDR; n = 43). Key exclusion criteria included those with type 1 diabetes and those with a known disorder which may alter IGF-I levels, such as acromegaly. Subjects underwent dilated fundoscopic examination and were tested for hemoglobin A1c, serum creatinine, and IGF-I between December 2009 and March 2010. IGF-I levels were measured via an immunoassay which had been calibrated against the new World Health Organization standard.
Amongst the groups, there was no statistical difference in age, race, or sex. There was a significant difference between the groups in body mass index, presence of macrovascular disease, duration of diabetes, hemoglobin A1c, insulin use, and serum creatinine. Overall, diabetic subjects had similar IGF-I levels compared to non-diabetic subjects (117.6 µg/L versus 122.0 µg/L, p = 0.497). The mean IGF-I levels for the groups were as follows: No DM = 122.0 µg/L, No BDR = 115.4 µg/L, NPDR = 118.3 µg/L, PDR = 119.1 µg/L. There was no significant difference in IGF-I levels amongst the study groups (p = 0.897). Amongst the diabetic groups, IGF-I levels were similar amongst insulin-dependent subjects and noninsulin-dependent subjects (116.8 µg/L versus 118.2 µg/L, p = 0.876). Univariate analysis of the IGF-I levels demonstrated statistical significance in regards to age (p = 0.002), body mass index (p = 0.008) and race (p = 0.040).
This study found no association between serum IGF-I levels and diabetic retinopathy and suggests that IGF-I is not a risk factor for the development of PDR.
This PDF is available to Subscribers Only