April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
An Intraocular OCT Probe
Jin H. Shen; John Kozub; Ratna Prasad; Karen M. Joos
Author Affiliations & Notes
  • Jin H. Shen
    Vanderbilt Eye Institute,
    Vanderbilt University, Nashville, Tennessee
  • John Kozub
    Physics & Astronomy Department,
    Vanderbilt University, Nashville, Tennessee
  • Ratna Prasad
    Vanderbilt Eye Institute,
    Vanderbilt University, Nashville, Tennessee
  • Karen M. Joos
    Vanderbilt Eye Institute,
    Vanderbilt University, Nashville, Tennessee
  • Footnotes
    Commercial Relationships  Jin H. Shen, pending (P); John Kozub, None; Ratna Prasad, None; Karen M. Joos, pending (P)
  • Footnotes
    Support  NIH Grant 1R21EY019752-02, NEI Core Grant in Vision Research 2P30EY008126-21, Joseph Ellis Family Research Fund, Unrestricted Departmental Grant from Research to Prevent Blindness, Inc. NY
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 1326. doi:
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      Jin H. Shen, John Kozub, Ratna Prasad, Karen M. Joos; An Intraocular OCT Probe. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1326.

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Abstract

Purpose: : Optical coherence tomography (OCT) has had a tremendous global health impact upon the current ability to diagnose, treat, and monitor multiple eye diseases. We propose that an intraocular OCT probe can be developed for intraoperative imaging.

Methods: : A miniature 25-gauge forward-imaging probe was designed, developed and optimized to use with an 850 nm spectral domain optical coherence tomography (SDOCT) system (Bioptigen, Inc.) Its imaging parameters were determined. The vitreous was removed from 10 fresh cadaver porcine eyes. A Q-switched Raman-shifted alexandrite laser (6.1 µm, 10 Hz, 0.6 mJ) was used to incise the retinas. The tissues were then imaged with the 25-gauge SDOCT probe.

Results: : A SDOCT probe was developed with the scanning driver within the handpiece. The SDOCT fiber-scanning probe transmits power of 500 µW. The axial resolution is 6 µm and the lateral resolution is 50-60 µm. The 25-gauge forward-imaging probe is currently able to image retinal blood vessels and lased retinal incisions when held 2 to 3 mm from the retina.

Conclusions: : A miniature intraoperative probe was developed that is capable of forward-imaging with SDOCT within the eye. It has the future potential to guide real-time intraocular surgery

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • retina • laser 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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