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Jens F. Kiilgaard, Jens Frederik Tebering; The Safety and Applicability of 25G Trans-vitreal Retino-choroidal Biopsies in Prognostic Testing of Malignant Choroidal Melanoma. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1431.
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To evaluate the safety and applicability of Trans-vitreal retino-choroidal (TVRC) biopsies obtained by a standard 25G vitrectomy equipment.
34 patients referred to Rigshospitalet with newly diagnosed malignant choroidal melanoma in the period September 2008 to February 2010 underwent TVRC biopsy for prognostic testing using standard 25G vitrectomy equipment. No internal tamponade nor laser was used. All Patients had a full ophthalmological examination. The biopsies were sent for histopathological evaluation and cytogenetic analysis (FISH).
Histopathological diagnosis could be given peroperatively in all cases. Chromosome 3 status could be obtained in 100% of the cases and in 84% of the cases additional information on chromosome 1, 6 and 8 could be found. Retina reattached in all cases and no endophthalmitis were seen. No cases of vitreal seeding of tumor cells was seen at follow up.
The use of a standard 25G vitrector for TVRC biopsy is a simple and safe procedure. All retinas reattached despite no internal tamponade or laser were used. The technique provides a peroperative diagnosis and enough tissue for prognostic testing.
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