April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Slow Increase In Thickness Of Presumed Choroidal Melanomas And Chromosome 3 Status
Author Affiliations & Notes
  • Emil Anthony T. Say
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Arman Mashayekhi
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Carol L. Shields
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Jerry A. Shields
    Ocular Oncology, Wills Eye Institute, Philadelphia, Pennsylvania
  • Footnotes
    Commercial Relationships  Emil Anthony T. Say, None; Arman Mashayekhi, None; Carol L. Shields, None; Jerry A. Shields, None
  • Footnotes
    Support  Retina Research Foundation of the Retina Society (CLS), Paul Kayser International Award of Merit in Retina Research (JAS), Eye Tumor Research Foundation (JAS, CLS)
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 1434. doi:
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Emil Anthony T. Say, Arman Mashayekhi, Carol L. Shields, Jerry A. Shields; Slow Increase In Thickness Of Presumed Choroidal Melanomas And Chromosome 3 Status. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1434.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract
 
Purpose:
 

To study the status of chromosome 3 in choroidal melanomas showing slow increase in thickness without a concomitant increase in basal diameter.

 
Methods:
 

Ten cases of choroidal melanoma with ultrasonographic evidence of increased thickness without photographic evidence of increased basal diameter were treated with Iodine-125 plaque radiotherapy from November 2005 to January 2009. Fine-needle aspiration biopsy for cytogenetic evaluation was performed at the time of plaque radiotherapy using a transvitreal approach with a 27-gauge needle for post-equatorial tumors and a direct transscleral approach with a 30-gauge needle for pre-equatorial tumors.

 
Results:
 

The mean age at presentation was 55 years (range, 39-74 years) and 3 patients were male. Mean maximal basal diameter was 9 mm (range, 7-12 mm) and mean thickness was 2.3 mm (range, 1.5-3.9 mm) at initial visit. Overlying orange pigment and associated subretinal fluid were absent in all cases. After a mean observation period of 56 months (range, 6-165 months), there was a mean increase in thickness of 0.7 mm (range, 0.2-1 mm) without concomitant increase in basal diameter and tumor thickness was greater than 2 mm in 9 cases (90%). Subretinal fluid had developed in 5 cases and new symptoms in one case. All tumors were found to have disomy of chromosome 3 on cytogenetic evaluation. There were no instances of local tumor recurrence or distant metastasis following plaque radiotherapy during a mean follow-up of 29 months (range, 9-51 months).

 
Conclusions:
 

Presumed choroidal melanomas showing isolated and slow increase in thickness without concomitant increase in basal diameter are most often associated with disomy of chromosome 3 and excellent life prognosis.

 
Keywords: melanoma • uvea • genetics 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×