Purchase this article with an account.
Alexander K. Schuster, Joachim E. Fischer, Lisa M. Michaels, Urs Vossmerbaeumer; Width Of Anterior Chamber Angle Determined By Oct And Correlation To Refraction In A German Working Population: The Miph Eye&Health Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1474.
Download citation file:
© ARVO (1962-2015); The Authors (2016-present)
The MIPH-EADS Eye&Health Study is an epidemiological study within the staff of a European aerospace company with the goal to monitor ocular and systemic risk factors of work-related health conditions. The purpose of the reported subset is to determine the geometry of the anterior chamber angle by use of a spectral-domain OCT and to establish quantitative correlations between the width of the angle, the refraction and intraocular pressure.
Out of 4617 eyes (2309 subjects) those with refractive errors of +3 diopters (D) were identified by refraction measurement (KR-8800, Topcon Inc., Japan) and examined using the anterior segment mode of a spectral-domain 3D OCT-2000 (Topcon Inc., Japan). Non-contact tonometry was performed (CT-80, Topcon Inc., Japan). As reference group we had 108 eyes of 54 emmetropic subjects (+/- 0.5 D). Previous ocular surgery was exclusion criterion. Width of the chamber angle was determined by using newly developed and validated semi-automated software tools and statistical analysis (Pearson correlation, ANOVA, regression analysis) was performed using SPSS 18.0 (Chicago, USA).
In this study, 668 eyes of 398 persons were included. Valid chamber angle OCT measurements could be obtained from 60 (72.3%) hyperopic and 412 (76.5 %) myopic eyes meeting the inclusion criteria. Mean hyperopic refraction was +4.7 D (+3 D - +8.75 D), mean myopic refraction was -5.9 D (-4 D - -14.75 D). The mean width of the chamber angle was 30.7° (13.5° - 45.6°, SD 7.4°) in the hyperopic group, 40.7° (19.3° - 66.0°, SD 8.2°) in the myopic group and 36.4° (21.1° - 51.8°, SD 6.7°) in the reference group. Correlation was highly significant (p<0.001) between refractive error and the aperture of the chamber angle as measured from OCT. Validation coefficients were between 0.88 and 0.95.
Our results highlight the correlation between refraction and aperture of the angle in hyperopia and myopia as determined by OCT-2000. The understanding of this relationship may be helpful in using OCT technology as a diagnostic tool in risk assessment of narrow angle situations.
This PDF is available to Subscribers Only