Long-term Survey Of The Antibiotic Susceptibility Trends Of Ocular Isolates At The Quinze-vingts National Eye Hospital (france)

Abstract

 

Purpose:

 

Management of infections is supported by knowledge of the trends of susceptibility of Bacteria to antibiotics. The aim of this study is to analyse the evolution of antibiotic susceptibilities of ophthalmic isolates in our Center during the last 13 years.

 

Methods:

 

Analysis of the year by year results (1996-2009) was performed for treating uncertainty and to explore alternatives of change in the environment on the long-term trends of antibiotic testing (diffusion technique SFM and EUCAST). Statistical contingency analysis was used for treating uncertainty and to explore the effects on changes in the environment. This analysis relies on stochastic ordering of the rows to test the assumption that a decrease (or increase) in susceptibility of Bacteria to antibiotics has taken place against the alternative that has not happened.

 

Results:

 

NS: non-statistically significant variation, SD: significant decrease, SI: significant increase.

 

Conclusions:

 

Empiric administration of antibiotics to treat non susceptible Bacteria lead to treatment failures, requiring additional courses of antibiotics which select additional non susceptible strains and fewer treatment options remain available. In the 90’s the patterns of evolution of antibiotic susceptibilities has lead our group to recommend rational use of antibiotics (matched with pathogen susceptibilities associated with ophthalmic infections), which starts to show positive effects, with a statistically significant increase in several antibiotic susceptibilities.  

 

Keywords: antibiotics/antifungals/antiparasitics • clinical (human) or epidemiologic studies: prevalence/incidence • bacterial disease