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Onsiri Thanathanee, Darlene Miller, Terrence P. O'Brien, Eduardo C. Alfonso, Carl P. Schaffner, David Ringel; Comparative In Vitro Antifungal Susceptibility Activity of Amphotericin B and Amphotericin B Methyl Ester for Candida albicans Endophthalmitis Isolates. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1502.
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To compare in vitro susceptibility of amphotericin B and amphotericin B methyl ester (a more soluble and less toxic formula of amphotericin B) against Candida albicans isolates recovered from endophthalmitis
The in vitro susceptibility of amphotericin B and amphotericin B methyl ester were determined and compared for Candida albicans isolates recovered from endophthalmitis (N =10) and Candida albicans ATCC reference strain 90028 using Clinical and Laboratory Standards Institute M27-A2 (NCCLS/CLSI) broth dilution method. All isolates were obtained from anterior chamber or vitreous humor within the last 5 years
The MICs of amphotericin B methyl ester were equal or superior to amphotericin B in most isolates (7 of 10 isolates). MIC90 value of both drugs were equal (1 µg/ml); however, the range of amphotericin B methyl ester (0.125-1 µg/ml) was slightly superior to amphotericin B (0.5-1 µg/ml). The MIC of quality control strain (ATCC® 90028) was within an acceptable range
Amphotericin B methyl ester was equal or superior against Candida albicans compared to amphotericin B in vitro. This formula may offer a more efficient and less toxic for the treatment of ocular mycoses
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