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Rong-Fang Wang, Janet B. Serle; The Effect of Age on Aqueous Humor Dynamics in Normal Monkey Eyes. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1515.
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A retrospective study was carried out to determine the effect of age on aqueous humor dynamics in normotensive monkey eyes.
Based on the monkey life cycle, nomotensive female cynomolgus monkeys were categorized as young age 3-5 yrs, middle age 6-10 yrs, and older age 11-15 yrs. Intraocular pressure (IOP) and outflow facility (C) were measured by an electronic indentation tonograph in a total of 33 monkeys. Aqueous humor flow rates (F) were measured by a scanning computerized fluorophotometer in 25 monkeys. Multiple measurements of IOP, C and F were performed in most monkeys at different ages. IOP and C were measured in 15 monkeys at 2 age categories, and 4 monkeys at 3 age categories. 7 monkeys had F measured at 2 age categories. For each monkey, the average of right and left eyes was used for statistical analysis.
The results are shown in Table 1. A reduction (p<0.001) of C was found comparing young, middle and old age groups. IOP was higher (p<0.05) in old age group than in young or middle age group. F was not (p>0.20) different among 3 age groups.
In the normotensive aging monkey eye, IOP increases, tonographic outflow facility decreases and aqueous humor flow rates are unchanged. It remains to be determined if this age-associated reduction in outflow facility affects the assessment of ocular hypotensive agents.
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