April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
A Comparison of Biometric Properties of the Isolated Human Lens Derived from Optical Coherence Tomography, Ultrasound Biomicroscopy and Shadowphotogrammetry
Derek Nankivil; Raksha Urs; Bianca Maceo; Esdras Arrieta; Fabrice Manns; Arthur Ho; Robert Augusteyn; Jean-Marie Parel
Author Affiliations & Notes
  • Derek Nankivil
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • Raksha Urs
    Department of Ophthalmology, Columbia University Medical Center, New York, New York
  • Bianca Maceo
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida
  • Esdras Arrieta
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
  • Fabrice Manns
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Biomedical Optics and Laser Laboratory, Department of Biomedical Engineering, University of Miami College of Engineering, Coral Gables, Florida
  • Arthur Ho
    Brien Holden Vision Institute, Sydney, Australia
    School of Optometry & Vision Science, University of New South Wales, Sydney, Australia
  • Robert Augusteyn
    Vision Cooperative Research Centre, Sydney, Australia
  • Jean-Marie Parel
    Ophthalmic Biophysics Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida
    Vision Cooperative Research Centre, Sydney, Australia
  • Footnotes
    Commercial Relationships  Derek Nankivil, None; Raksha Urs, None; Bianca Maceo, None; Esdras Arrieta, None; Fabrice Manns, None; Arthur Ho, None; Robert Augusteyn, None; Jean-Marie Parel, None
  • Footnotes
    Support  NIH 2 RO1 EY14225, Australian Governments CRC Program (Vision CRC), Florida Lions Eye Bank, NIH Center Grant P30 EY14801, Research to Prevent Blindness and the Henri and Flore Lesieur Foundation (JMP)
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 1545. doi:
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      Derek Nankivil, Raksha Urs, Bianca Maceo, Esdras Arrieta, Fabrice Manns, Arthur Ho, Robert Augusteyn, Jean-Marie Parel; A Comparison of Biometric Properties of the Isolated Human Lens Derived from Optical Coherence Tomography, Ultrasound Biomicroscopy and Shadowphotogrammetry. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1545.

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Abstract

Purpose: : To compare calculations of equatorial diameter, central thickness, and cross-sectional area of isolated human lenses measured using three different modalities.

Methods: : Optical coherence tomography (OCT) (Uhlhorn et al, Vis Res, 2008), ultrasound biomicroscopy (UBM) and shadowphotogrammetric (SP) images of 3 whole human lenses (66, 33 & 51 years, 24, 38 & 41 hours PMT) and one baboon lens (25 years, 22 hours PMT) immersed in Dulbecco’s Modified Eagle Medium at room temperature were obtained in sequence within 2 hours. Lens contours were extracted and then fit with a 10th order even Fourier series (Urs et al, Vis Res, 2010). Equatorial diameter, central thickness and cross-sectional area were calculated in terms of the fit parameters, and the uncertainty of each was estimated with an error-model analysis. Hypothesis tests were performed to determine any differences between the three measurement systems.

Results: : The average differences in the measures of diameter, thickness and cross-sectional area between the three systems were (0.7 ± 2.3)%, (0.1 ± 5.3)% and (1.0 ± 1.9)% respectively. Differences between these parameters measured with the three systems, although occasionally significant, were not consistent for all eyes, suggesting variation in lens alignment as the source of the discrepancy. SP provided more dense contours that matched the Fourier model best, giving SP better precision than OCT or UBM for the diameter, thickness and cross-sectional area (p < 0.02).

Conclusions: : OCT, UBM and SP images provide comparable estimates of lens diameter, thickness and cross-sectional area.

Keywords: imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) 
© 2011, The Association for Research in Vision and Ophthalmology, Inc., all rights reserved. Permission to republish any abstract or part of an abstract in any form must be obtained in writing from the ARVO Office prior to publication.
Copyright © 2024 Association for Research in Vision and Ophthalmology.
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