April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Two-year Follow-up Of Subfoveal Pigment Epithelial Detachment In Eyes With Age-related Macular Degeneration And Visual Acuity Better Than 20/40
Author Affiliations & Notes
  • Takayuki Baba
    Ophthalmology & Visual Science, Chiba Univ Grad School of Med, Chiba, Japan
  • Masayasu Kitahashi
    Ophthalmology & Visual Science, Chiba Univ Grad School of Med, Chiba, Japan
  • Mariko Kubota-Taniai
    Ophthalmology & Visual Science, Chiba Univ Grad School of Med, Chiba, Japan
  • Emi Ohoka
    Ophthalmology & Visual Science, Chiba Univ Grad School of Med, Chiba, Japan
  • Shuichi Yamamoto
    Ophthalmology & Visual Science, Chiba Univ Grad School of Med, Chiba, Japan
  • Footnotes
    Commercial Relationships  Takayuki Baba, None; Masayasu Kitahashi, None; Mariko Kubota-Taniai, None; Emi Ohoka, None; Shuichi Yamamoto, None
  • Footnotes
    Support  Japan Society for the Promotion of Science, Grant-in-aid for Young Scientists (Start-up) 22890028
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 1679. doi:https://doi.org/
  • Views
  • Share
  • Tools
    • Alerts
      ×
      This feature is available to authenticated users only.
      Sign In or Create an Account ×
    • Get Citation

      Takayuki Baba, Masayasu Kitahashi, Mariko Kubota-Taniai, Emi Ohoka, Shuichi Yamamoto; Two-year Follow-up Of Subfoveal Pigment Epithelial Detachment In Eyes With Age-related Macular Degeneration And Visual Acuity Better Than 20/40. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1679. doi: https://doi.org/.

      Download citation file:


      © ARVO (1962-2015); The Authors (2016-present)

      ×
  • Supplements
Abstract

Purpose: : To investigate the clinical course of subfoveal pigment epithelial detachments (PEDs) in eyes with age-related macular degeneration (AMD) and visual acuity better than 20/40.

Methods: : Retrospective interventional case series. Thirty-seven eyes of 35 cases (men 29, women 6) were studied. The mean age of the patients was 67.7 years with a range from 53 to 81 years. This study was approved by the Institutional Review Board, and an informed consent was obtained from every patient. All cases had a subfoveal PED larger than one disc area, and all were diagnosed with exudative AMD. The cases were divided into three groups by the type of PED; non-vascularized PED (Group A, 14 eyes), vascularized PED including polypoidal vasculopathy (PCV, Group B, 15 eyes), and occult choroidal neovascularization (CNV, Group C, 8 eyes). The best-corrected visual acuity (BCVA) was better than 20/40 in all eyes with a range of 20/20-20/40 (median, 20/30). The eyes were treated with intravitreal bevacizumab or ranibizumab when the BCVA decreased or metamorphopsia increased. The BCVA, central foveal thickness (CFT), and PED thickness measured by FD-OCT at baseline were compared to that two years after the initial presentation.

Results: : The BCVA did not change in Group A, decreased from 0.06±0.11 to 0.33±0.50 logMAR units in Group B, and decreased from 0.09±0.12 to 0.67±0.79 logMAR units in Group C. The CFT and PED thickness did not change significantly in all groups. However, the number of cases with a completely resolved PED was significantly larger in Group B (5 cases, P=0.014). The number of cases requiring treatment was highest in Group C (7 cases, P=0.022). The mean number of injection was 3.0 in Group A, 4.0 in Group B, and 3.0 in Group C.

Conclusions: : The BCVA is maintained in cases with non-vasucularized PED regardless of the duration of the PED, while one-half of the cases with vascularized PEDs had BCVA worse than 20/40 at the two year follow-up. The clinical course of subfoveal vascularized PEDs with good BCVA is different from that in eyes with non-vascularized PEDs.

Keywords: age-related macular degeneration • retinal pigment epithelium • visual acuity 
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×