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Nitin Jain, Manju Chandran, Sr., Narendran Nair, Gulrez Ansari, Leena Bhat, Lorraine North, Emily Turton, Geeta Menon; Correlation Between Change In Visual Acuity (va) And Lesion Size After Two Regimes Of Intravitreal Bevacizumab In Age Related Macular Degeneration(armd) With Minimally Classic And Occult Choroidal Neovascularisation. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1688.
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To investigate the correlation between change in VA and lesion size after two regimes of intravitreal Bevacizumab in ARMD with Minimally Classic and Occult choroidal neovascularisation.
Retrospective review of 88 eyes (87 patients) treated with intravitreal injection of Bevacizumab were randomised into two groups. Group I had intravitreal Bevacizumab 1.25mg administered 6 weekly for three visits and then Pro Re Nata (PRN). Group II had intravitreal Bevacizumab PRN after the first dose. Follow up was 6 weekly for a period of 1 year . Changes in VA as measured by Early Treatment Diabetic Retinopathy Study (ETDRS) charts at baseline and after 12 months were analysed. We also compared the differences in the lesion size before and after treatment. In addition we examined the correlation of the change in VA with lesion size.
Mean change in VA before and after treatment showed a 0.66 improvement for Group 1, and 2.41 deterioration for Group 2. Visual acuity before and after treatment was not significantly different for either group (Group 1: p=.767; Group 2: p=.232, paired t-test). Mean change in lesion size before and after treatment showed an improvement, reducing by 1.87 in Group 1 and 3.00 in Group 2. Lesion size for both groups was significantly reduced (Group 1: p<.001; Group 2: p<.001, Wilcoxon signed ranks test). A correlation was observed between the change in VA and change in lesion size for Group 1, but not Group 2 (Group 1: r= -.352, p<.05; Group 2 r=3.22, p =.052, Pearsons correlation).
VA showed improvement in Group I with significant reduction in lesion size. In addition a correlation was observed between the change in VA and lesion size in Group I. In our small study Group I with initial loading dose was more effective than Group 2.
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