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Ramzi G. Sayegh, Christian Simader, Adrijana Prvulovic, Bernhard Baumann, Christopher G. Kiss, Michael Pircher, Christopher Schuetze, Erich Goetzinger, Christoph K. Hitzenberger, Ursula Schmidt-Erfurth; Automated Lesion Size Quantification of Geographic Atrophy using Polarization-Sensitive Spectral Domain Optical Coherence in Comparison to Fundus Autofluorescence in a Follow-up Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1707.
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The purpose of this study is to evaluate the performance of polarization sensitive spectral domain optical coherence tomography (PS-SD-OCT) and a custom software in determining the atrophy lesion area in patients with geographic atrophy (GA) secondary to age related macular degeneration (AMD) in comparison to fundus autofluorescence (FAF) in a follow up study.
12 eyes of 12 patients with GA were examined by PS-SD-OCT and FAF at baseline, month 3 and month 6. Using a novel segmentation algorithm, PS-SD-OCT is capable of detecting and quantifying automatically the integrity of the retinal pigment epithelium (RPE) and therefore the region of atrophy in GA. The lesion size determined in PS-SD-OCT was compared with the lesion size measured using FAF imaging, in order to validate the clinical applicability of this novel imaging method.
PS-SD-OCT enables in a single imaging modality the differentiation of all retinal layers as well as determining depolarizing elements in the retina such as the RPE. Mean lesion size detected by PS-SD-OCT was 6.35mm² at baseline, 7.12 mm² at visit 1, and 7.69mm² at month 6. The automatically detected area of atrophy by PS-SD-OCT correlated significantly with the hypofluorescent area representing the area of atrophy measured by FAF at each visit (p< 0.05).
This study shows that follow-up of patients with GA secondary to AMD is possible using an automated RPE atrophy lesion size detection software implemented in a PS-SD-OCT system. PS-SD-OCT may therefore be a useful modality for the automatic determination of GA lesion size detection and follow up.
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