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Tae Kwann Park, In Hwan Cho, Young-Hoon Ohn; Electroretinographic Assessment Of The Retinal Function During Intravitreal Bevacizumab Injections In Central Retinal Vein Occlusion. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1877.
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© ARVO (1962-2015); The Authors (2016-present)
To investigate the changes of electroretinogram(ERG) at baseline and during the first three times of intravitreal Bevacizumab injection in central retinal vein occlusion (CRVO) patients.
Thirteen eyes with thirteen CRVO patients who received three times of intravitreal Bevacizumab injection with an intervals of six weeks and who could be examined visual acuity, optical coherence tomography and ERG at 4 weeks after each injection, were included in this study. Unaffected fellow eye group and age-matched normal healthy group were determined as control groups and their each ERG results were compared with affected group.
Amplitudes of rod b wave, a, b wave of maximal combined response and cone response, oscillatory potentials and 30Hz flicker significantly decreased in affected group than control groups (P<0.001). After injection, amplitudes of the above-mentioned all ERG parameters gradually increased during the 1st and the 2nd injection (P<0.001). However, there was no significant difference between 4 weeks later after each 2nd and 3rd injection (P>0.05). Even 4 weeks later after the 3rd injection, amplitudes of all ERG parameters were significantly lower than control groups (P<0.001).
Intravitreal Bevacizumab injection significantly improved not only macular functions but also whole retinal functions which are examined by ERG in CRVO patients.
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