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Hyoung Jun Koh, Yong Min Kim; Long Term Evaluation of Recurrence after Combination of PDT with Anti-VEGF vs. Anti-VEGF Monotherapy for Polypoidal Choroidal Vasculopathy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2061.
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To evaluate the recurrence rate after photodynamic therapy (PDT) or intravitreal injections of anti-VEGF for polypoidal choroidal vasculopathy (PCV).
We retrospectively reviewed the medical records of 31 patients (31 eyes) with PCV which were followed up more than 2 years either after PDT and/or anti-VEGF. Baseline characteristics including visual acuity and recurrence rate were analyzed according to the treatment modality.
Of the 31 eyes, 16 were treated with anti-VEGF monotherapy and 15 were treated with combination of PDT with anti-VEGF. Mean follow-up was 32.4 ± 6.9 months. Initial time until macular dryness was 10.6 months in the anti-VEGF and 8.3 months in the combination group. Six eyes had persistent leakage without achieving dryness throughout follow-up period. Recurrence was noted in 20 eyes (80%), 100% in the anti-VEGF and 64% in the combination group. A Kaplan-Meier survival analysis showed higher recurrence rates in the anti-VEGF group than in the combination group (p=0.01). Mean time to recurrence was 8.7 months, 5.1 months in the anti-VEGF and 13.1 months in the combination group.
Recurrence rate of PCV was less, and time of recurrence after initial resolution of fluid was longer in the combination group than anti-VEGF monotherapy.
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