March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Long Term Evaluation of Recurrence after Combination of PDT with Anti-VEGF vs. Anti-VEGF Monotherapy for Polypoidal Choroidal Vasculopathy
Author Affiliations & Notes
  • Hyoung Jun Koh
    Ophthalmology, Yonsei Univ College of Medicine, Seoul, Republic of Korea
  • Yong Min Kim
    Ophthalmology, Yonsei Univ College of Medicine, Seoul, Republic of Korea
  • Footnotes
    Commercial Relationships  Hyoung Jun Koh, None; Yong Min Kim, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2061. doi:
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      Hyoung Jun Koh, Yong Min Kim; Long Term Evaluation of Recurrence after Combination of PDT with Anti-VEGF vs. Anti-VEGF Monotherapy for Polypoidal Choroidal Vasculopathy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2061.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the recurrence rate after photodynamic therapy (PDT) or intravitreal injections of anti-VEGF for polypoidal choroidal vasculopathy (PCV).

Methods: : We retrospectively reviewed the medical records of 31 patients (31 eyes) with PCV which were followed up more than 2 years either after PDT and/or anti-VEGF. Baseline characteristics including visual acuity and recurrence rate were analyzed according to the treatment modality.

Results: : Of the 31 eyes, 16 were treated with anti-VEGF monotherapy and 15 were treated with combination of PDT with anti-VEGF. Mean follow-up was 32.4 ± 6.9 months. Initial time until macular dryness was 10.6 months in the anti-VEGF and 8.3 months in the combination group. Six eyes had persistent leakage without achieving dryness throughout follow-up period. Recurrence was noted in 20 eyes (80%), 100% in the anti-VEGF and 64% in the combination group. A Kaplan-Meier survival analysis showed higher recurrence rates in the anti-VEGF group than in the combination group (p=0.01). Mean time to recurrence was 8.7 months, 5.1 months in the anti-VEGF and 13.1 months in the combination group.

Conclusions: : Recurrence rate of PCV was less, and time of recurrence after initial resolution of fluid was longer in the combination group than anti-VEGF monotherapy.

Keywords: age-related macular degeneration • photodynamic therapy • injection 
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