March 2012
Volume 53, Issue 14
ARVO Annual Meeting Abstract  |   March 2012
Results Of Brain Mri In Ocular Coloboma: Preliminary Results
Author Affiliations & Notes
  • Frederic Matonti
    Ophthalmology, Hopital Nord, Marseille, France
  • Nadine Girard
    Ophthalmology, Hopital de la Timone, Marseille, France
  • Annie Levy-Mozziconacci
    Ophthalmology, Hopital Nord, Marseille, France
  • Julie Berbis
    Ophthalmology, Hopital Nord, Marseille, France
  • Danièle Denis
    Ophthalmology, Hopital Nord, Marseille, France
  • Footnotes
    Commercial Relationships  Frederic Matonti, None; Nadine Girard, None; Annie Levy-Mozziconacci, None; Julie Berbis, None; Danièle Denis, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2087. doi:
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      Frederic Matonti, Nadine Girard, Annie Levy-Mozziconacci, Julie Berbis, Danièle Denis; Results Of Brain Mri In Ocular Coloboma: Preliminary Results. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2087.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : Congenital ocular colobomas are the result of a failure in closure of the embryonal fissure during organogenesis. We present a prospective study (2007-2011) in which we report imaging findings in children with ocular coloboma

Methods: : 41 children (64 eyes) were included; 18 boys, 23 girls with media age of 24,0 months (1.0-90.0) at first presentation. 2 or 3 month following a complete ophthalmologic examination, cerebral MRI was performed

Results: : Coloboma was bilateral in 23 cases and unilateral in 18 cases. Eleven various types of coloboma were distinguished. Of 64 eyes, 74% had papillary coloboma including 28 severe colobomas. On 41 MRI, abnormalities were present in 86%: gyration abnormalities (N = 22), ventricular dilatation (N = 18), dilatation of the perivascular spaces (N = 15), signal abnormalities and malformation of the brain stem (N = 15), signal abnormalities of white matter (N = 12), abnormalities of corpus callosum (N = 11). Most of these abnormalities were related. Gyration abnormalities were the most frequent. There was no significant difference between the severity of coloboma and abnormalities found (p = 1.0). The same absence of significant difference was found between gyration abnormalities and the severity of coloboma in children (p = 1.0)

Conclusions: : This study shows, for the first time, the existence of frequent cerebral abnormalities on MRI in children with eye coloboma with particularly gyration abnormalities

Keywords: imaging/image analysis: clinical • neuro-ophthalmology: diagnosis 

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