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Tito Fiore, Marco Lupidi, Barbara Iaccheri, Gianluigi Tosi, Daniela Fruttini, Amedeo Pieri, Alessia Iannone, Antonio Garritano, Carlo Cagini; Repeatability Of Retinal Macular Thickness Measurements In Patients With Diabetic Clinically Significant Macular Edema Using Two Different Scanning Protocols Of Spectralis Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2094.
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© ARVO (1962-2015); The Authors (2016-present)
To determine the repeatability of OCT Spectralis retinal thickness (RT) measurements in diabetic patients with clinical significant macular edema (CSME) using two different scanning methods.
Fifty-four eyes of 54 diabetic patients with CSME were included in the study. Repeatability and intrasession correlation coefficients were tested with 20 x 15 degree raster scans consisting of 19 (group I) or 37 (group II) high-resolution line scans that were repeated two times by 1 experienced examiner.
In diabetic patients, examining the five ETDRS inner areas, coefficient of repeatability was less than 2% for both group. Moreover, intrasession coefficients of variation for all ETDRS inner areas were less than 0.4% for both scanning protocols. Average ± SD thickness was found 396 ± 104 μm in group I and 390 ± 104 μm in group II. Mean absolute change in thickness ± SD was 0.5 ± 4.4 in group I and 0 ± 2.3 in group II. Mean relative change in thickness was 0.14% in group I and 0.1% in group II. No statistically significant differences were found between obtained measurement in group I and group II.
RT measurements in diabetic patients with CSME are repeatable using both scanning protocols (19 or 37 B-scans) with OCT Spectralis. The results indicate that a change in central subfield thickness exceeding 11 µm is likely to be real.
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