Abstract
Purpose: :
To examine if SD-OCT imaging is giving some more information than multifocal ERG about retinal toxicity in a group of 25 patients in long term treatment with hydoxychloroquine.
Methods: :
SD-OCT and multifocal ERG (Retinoscan) in 25 patients (50 eyes) after 5 years of hydroxychloroquine treatment were examined. In all of them a complete ophtalmological examination was performed. The entry criteria in both groups were BCVA 0.67 and better and negative Amsler grid test.
Results: :
No significant changes in OCT images were observed in 13 patients (22 eyes) with negative multifocal ERG. Small Retinal Pigment Epithelium (EPR) changes were observed in only 7 patients (10 eyes) of the 12 patients (22 eyes) with multifocal ERG abnormalities.
Conclusions: :
The correlation between OCT and multifocal ERG were statistically observed even if multifocal ERG seems to be a prognostic method more sensitive and relevant to find morfological and functional alterations from the beginning in patients with long term treatment with hydrochloroquine.
Keywords: drug toxicity/drug effects • receptors • imaging/image analysis: clinical