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Caroline Brandl, Horst Helbig, Maria A. Gamulescu; Choroidal Thickness Measurements During CSCR Treatment. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2129.
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To determine changes in choroidal thickness in patients with Central Serous Chorioretinopathy (CSCR) during the first 3 months after initial diagnosis via Enhanced Depth Imaging Spectral-Domaine Optical Coherence Tomography (EDI-OCT).
10 patients with initial diagnosis of CSCR, who had received no treatment so far, participated in this prospective study. Routine opthalmological investigation was complemented by EDI-OCT. Choroidal thickness was measured both in affected and fellow eyes at the fovea, 500µm and 1000µm both temporal and nasal. EDI-OCT scans were furthermore performed through the leakagepoint (if present), visualised via fluorescein angiography. Follow-up measurements (eye-tracker controlled) were performed after 2-3 weeks, 6-8 weeks and 3 months. Statistical significance was determined via Students T-Test (p-value < 0.05).
In patients with CSCR, average choroidal thickness not only demonstrated a significant thickening at baseline, but also showed a marked decrease after 3 months, however still not reaching normal levels. Additionally, choroidal thickening was also present in fellow eyes at baseline, but less prominent and only slightly decreased during follow up.
Clinical Trial: :
Regensburg Ethical Committee, 10-101-0213
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