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Kyungmoo Lee, Young Kwon, Mona K. Garvin, Meindert Niemeijer, Milan Sonka, Michael Abràmoff; Correlation of Retinal Ganglion Cell Damage and Optic Nerve Axonal Loss in Early Glaucoma Using SD-OCT. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2150.
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To test the hypothesis that, in early glaucoma, retinal ganglion cell layer (GCL) damage is accompanied by optic nerve head (ONH) neural rim loss using spectral domain optical coherence tomography (SD-OCT).
Macular and peripapillary OCT scans (200 × 200 × 1024 voxels, 6 × 6 × 2 mm3) were obtained from left eyes of 58 glaucoma patients and suspects (62.9 ± 14.8 years, 34.5% male) using a CirrusTM HD-OCT machine (Carl Zeiss Meditec, Inc., Dublin, CA). OS images were flipped in a standard fashion. The ganglion cell layer was automatically detected in macular scans by a graph-theoretic approach. Optic disc was segmented from peripapillary scans using a voxel-column classification method. The mean macular GCL thickness in 68 square regions and the neuroretinal rim area in 12 wedge-like regions were measured in the macular and peripapillary scans which were mutually registered in the en-face plane. Each regional GCL thickness was correlated with 12 regional rim areas so that the regional rim area with the highest squared Pearson’s correlation coefficient (r2) was identified.
The regional GCL thickness across all macular regions had mean (± SD) highest r2 correlation coefficient of 0.178 ± 0.105 with the regional rim area of the ONH. Figures 1C, D show the correspondence of the regional GCL thickness and the regional rim area with the maximum correlation and their highest r2 correlation coefficient, respectively.
In pre- and early glaucoma, retinal ganglion cell body damage is accompanied by corresponding optic nerve head axonal loss, and this structural damage can be detected using automated image analysis of SD-OCT.
Figure 1. (A) En-face registration of macular and peripapillary OCT projection images. (B) Macular grid including 68 regions (regions 1 - 68) and neuroretinal rim grid including 12 regions (regions a - l). (C) Color-coded correspondence map between regional mean macular GCL thickness and regional rim area. (D) Color-coded highest r2 correlation coefficient map between regional mean macular GCL thickness and regional rim area.
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