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Alessandro Invernizzi, Andrea Giani, Mario Cigada, Giovanni Staurenghi; Retrobulbar Structures Visualization With Enhanced Depth Imaging Optical Coherence Tomography. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2153.
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To assess the feasibility of enhance depth imaging optical coherence tomography (EDI-OCT) to visualize deep structures of the bulb and retrobulbar tissues in myopic eyes. To evaluate which elements of the eye influence this capability.
30 consecutive myopic eyes (refractive error <-6 diopters) from 21 patients were selected for the study. Any pathological condition affecting the posterior pole of the eye was considered as exclusion criteria. Each patient underwent visual acuity test and non-contact biometry to asses axial length. EDI-OCT scans were obtained with the HRA+Spectralis (Heidelberg Engineering, Heidelberg, Germany). In all the eyes choroidal thickness was measured manually. The presence of a visualisable sclera was assessed. In eyes with a full visible sclera, scleral thickness was measured manually. The capability of visualise structures beyond the sclera was assessed. All manual measurements were performed twice by two indipendent operators. A paired T-test was used to assess measurements repeatability.The influence of axial length, refractive error, mean choroidal thickness and mean scleral thickness (if visible) on EDI-OCT capability in visualizing structures beyond the choroid was tested by a multifactorial regression analysis with a generalized linear model (GLM) for binomial variables (logit).
In all the observed eyes the choroid was entirely visible and measurable. In 11 of 30 eyes the sclera was not completely visualisable (GROUP1). In 19 eyes the full scleral thickness was detectable and measurable (GROUP2). Measurements repeatability was good, both for choroid (p = 0.20), and for sclera (p = 1.00). In 7 out of 19 eyes in GROUP2 the full sclera was the deepest structure detectable. In the remaining 7 eyes in GROUP2 some deeper structures were visualisable beyond the sclera. According to the GLM analysis, choroidal thickness was the only parameter significantly correlated with the capability of visualising the full sclera (p<0.0001) and the structures deeper than it (p = 0.013).
EDI-OCT allowed visualizing the choroid in all the eyes included in this study. Scleral thickness and retrobulbar structures were not always visible. Choroidal thickness was the only parameter significantly correlated with EDI-OCT capability of visualizing deeper structures.
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