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Jennifer C. lee, Brandon Wong, Elnaz Rakhshan, Ou Tan, Srinivas R. Sadda, David Huang, Amani A. Fawzi; Retinal Blood Flow In Proliferative Diabetic Retinopathy By Fourier-domain Optical Coherence Tomography: Measurements Before And After Panretinal Photocoagulation. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2154.
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The purpose of this study is to determine retinal venous blood flow in proliferative diabetic retinopathy(PDR) as compared to normal eyes using Doppler Fourier-domain optical coherence tomography(FD-OCT), and to determine the effect of panretinal photocoagulation(PRP) on retinal blood flow.
This is a prospective interventional pilot study. Inclusion criteria were a clinical diagnosis of PDR without prior PRP or vitreous hemorrhage. Double circular Doppler scans of peripapillary blood vessels were performed using the RTVue FD-OCT system (Optovue Inc., Fremont, CA, USA). Retinal blood flow was measured according to a previously described method where candidate vessels are chosen by computer algorithms and in post-processing the reader manually refines the results. Total retinal blood flow was measured by summing the flow from all detectable veins. Pre-PRP Doppler FD-OCT scans were analyzed for all PDR subjects (6), and post-PRP Doppler FD-OCT scans were analyzed on four of them at the time of submission.
Blood flow at baseline was not significantly different between PDR and control eyes (p=0.86), however, post-PRP there was a trend for decreasing blood flow in PDR (p=0.06). Compared to controls, PDR eyes had statistically significant decrease in venous velocity at baseline (p=0.01) and post- PRP laser (p=0.01), along with statistically non-significant increased venous caliber (p=0.15) (Table 1).
Retinal venous velocity is slower in PDR eyes compared to normal eyes. There is a trend towards decreased total retinal blood flow in the early 7-8 weeks post-PRP period. Additional patients and sequential post-PRP follow-up are ongoing to further characterize the retinal vascular effects of PDR and PRP treatment.
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