March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Combined Functional And Morphologic Parameters In Geographic Atrophy: A Longitudinal Study
Author Affiliations & Notes
  • Elisabetta Pilotto
    Department of Ophthalmology,
    University of Padova, Padova, Italy
  • Francesca Guidolin
    Department of Ophthalmology,
    University of Padova, Padova, Italy
  • Enrica Convento
    Department of Ophthalmology,
    University of Padova, Padova, Italy
  • Luigi Spedicato
    Department of Ophthalmology,
    University of Padova, Padova, Italy
  • Stela Vujosevic
    Fondazione GB Bietti-IRCCS, Padova, Italy
  • Fabiano Cavarzeran
    Department of Ophthalmology,
    University of Padova, Padova, Italy
  • Edoardo Midena
    Ophthalmology,
    University of Padova, Padova, Italy
    Fondazione G.B. Bietti per l’Oftalmologia, IRCCS, Roma, Italy
  • Footnotes
    Commercial Relationships  Elisabetta Pilotto, None; Francesca Guidolin, None; Enrica Convento, None; Luigi Spedicato, None; Stela Vujosevic, None; Fabiano Cavarzeran, None; Edoardo Midena, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2157. doi:
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      Elisabetta Pilotto, Francesca Guidolin, Enrica Convento, Luigi Spedicato, Stela Vujosevic, Fabiano Cavarzeran, Edoardo Midena; Combined Functional And Morphologic Parameters In Geographic Atrophy: A Longitudinal Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2157.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract 
 
Purpose:
 

To analyze on a long term basis microperimetry, standard short-wavelenght (SW-FAF) and near infrared-wavelenght fundus autofluorescent (NIR-FAF) changes in eyes with geographic atrophy (GA) secondary to age-related macular degeneration.

 
Methods:
 

Fourteen consecutive patients (20 eyes) affected by GA were studied by means of microperimetry to assess fixation and retinal sensitivity changes every six months during follow-up. All patients performed SW-FAF and NIR-FAF at any follow-up visit.

 
Results:
 

Mean follow-up was 12.26 ± 4.45 months. Total hypoFAF area was always significantly wider in NIR-FAF than in SW-FAF (5.05 ± 2.40 mm2 vs 4.45 ±± 2.41 mm2, p=0.012 at baseline; 5.78 ±2.87 mm2 vs 5.21 ± 2.77 mm2, p<0.0001 at last follow-up visit). The mean GA enlargement was +0.76 ± 1.24 mm2/year in SW-FAF and +0.92 ±1.10 mm2/year in NIR-FAF. Mean retinal sensitivity significantly decreased from 7.79 ± 4.02 dB to 6.76 ± 4.50 dB (p=0.006). 47.3% of the relative dense scotoma (≤ 5 dB) tested points at baseline evolved to absolute scotoma. Relative scotomata characterized by hypoSW-FAF or hyperNIR-FAF had a higher risk of evolving to absolute scotoma respectively than normo- and hyper-FAF in SW-FAF (O.R.=2.70 and O.R.=2.68, respectively), and normo- and hypo-FAF in NIR-FAF (O.R.=3.20 and O.R.=2.17 respectively).

 
Conclusions:
 

SW-FAF, compared to NIR-FAF, may underestimate the baseline extension and progression of GA. Different FAF patterns, assessed by SW-FAF and NIR-FAF, have different relative risk of GA progression. SW-FAF should be integrated with NIR-FAF in the follow-up of GA from both a morphological and functional perspective.

 
Keywords: age-related macular degeneration • imaging methods (CT, FA, ICG, MRI, OCT, RTA, SLO, ultrasound) • perimetry 
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