March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
To Evaluate The Influence Of The Duration Of Flicker Light Provocation On Retinal Vessel Dilation
Author Affiliations & Notes
  • Rebekka Heitmar
    Optometry and Vision Sciences, Aston University, Birmingham, United Kingdom
  • Robert J. Summers
    Optometry and Vision Sciences, Aston University, Birmingham, United Kingdom
  • Footnotes
    Commercial Relationships  Rebekka Heitmar, None; Robert J. Summers, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2174. doi:
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      Rebekka Heitmar, Robert J. Summers; To Evaluate The Influence Of The Duration Of Flicker Light Provocation On Retinal Vessel Dilation. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2174.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To evaluate the influence of the duration of flicker-light provocation on retinal vessel dilation.

Methods: : Twelve healthy individuals (mean age 32 +/-7 yrs) underwent continuous retinal vessel diameter measurement of both arterioles and venules using the DVA (Dynamic Retinal Vessel Analyser; Imedos Systems, Germany). Each subject underwent four measurement protocols, in a random order, comprising 50s baseline measurement followed by 3 cycles each of 5, 7, 10 or 20s flicker-light stimulation and 80s recovery (total duration: 305-350s).

Results: : A stepwise forward regression analysis revealed no influence of age, vessel diameter, blood or intra ocular pressure on retinal arteriolar or venular dilation due to flicker provocation. Retinal vessel diameter changes (maximum dilation, maximum constriction and dilation amplitude) due to flicker-light provocation were independent of flicker duration for arteries (F(3,43)=0.7, p=0.571) and veins (F(3,43)=2.5, p=0.075).

Conclusions: : Shorter stimulation protocols may be sufficient to evaluate vessel function. In addition, shorter protocols are also more suitable for those with fixation problems.

Keywords: retina • imaging/image analysis: clinical • discrimination 
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