Comparison Of Retinal Sensitivity In Normal Subjects Using Two Types Of Microperimetry Devices

Abstract

 

Purpose:

 

To evaluate the comparability and potential correlation of retinal light sensitivity obtained by Nidek MP-1™ (Nidek Technologies, Italy) and OPKO Spectral-OCT/SLO™ (OPKO Health Inc., USA).

 

Methods:

 

Subjects with no known ocular diseases were enrolled in the study. The inclusion criteria were best-corrected visual acuity of 20/20 or better with a refractive error within ±6 diopters (D) and astigmatism within ±1.0 D. Both eyes of each subject were tested using MP-1 and the Spectral-OCT/SLO™. The test settings are summarized in Table 1.

 

Results:

 

14 normal subjects (25 eyes) with a mean age of 31 years (range: 20-45 years) were enrolled. 3 eyes were excluded due to poor foveal fixation or high refractive error. The mean spherical equivalent refractive error was -2.47DS (range +0.50 to -6.00 DS). The results of the retinal light sensitivity comparisons are summarized in Table 2. The sensitivity of the 4 central points in the pattern was also evaluated and the results are summarized in Table 3.

 

Conclusions:

 

The lack of correlation between MP1 and SD OCT/SLO™ may be explained by the intrinsic difference in background luminance between devices and stimulus attenuation scale, creating different stimulus-contrast and retinal light adaption. Our pilot study has shown that it is unlikely for the MP1 and SD OCT/SLO to be used interchangeably. SD OCT/SLO™ offers a wider range of sensitivity detection, which may allow finer differentiation of retinal sensitivity. However, additional studies, with a greater number of subjects among other factors, are indicated to confirm our findings.  

 

Keywords: perimetry • differentiation • clinical (human) or epidemiologic studies: systems/equipment/techniques