April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Relationship between Pinguecula and Diabetes Mellitus
Author Affiliations & Notes
  • Tatsuya Mimura
    Department of Ophthalmology, Toranomon Hospital, Minato-ku, Japan
  • Mikiro Mori
    Department of Ophthalmology, Toranomon Hospital, Minato-ku, Japan
  • Tomohiko Usui
    Ophthalmology, Univ of Tokyo Sch of Med, Tokyo, Japan
  • Shiro Amano
    Ophthalmology, Univ of Tokyo School of Medicine, Bunkyo-Ku, Japan
  • Footnotes
    Commercial Relationships  Tatsuya Mimura, None; Mikiro Mori, None; Tomohiko Usui, None; Shiro Amano, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 1940. doi:
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      Tatsuya Mimura, Mikiro Mori, Tomohiko Usui, Shiro Amano; Relationship between Pinguecula and Diabetes Mellitus. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1940.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To assess the relationship between age and the incidence and severity of pinguecula in patients with diabetes mellitus, and to compare the grade of pinguecula between control subjects and patients with diabetes.

Methods: : A total of 160 patients with type 2 diabetes aged 31 to 70 years (DM group) and 160 control subjects aged 31 to 70 years (Control group) were enrolled. The grade of pinguecula at two locations (nasal and temporal) was assessed in all subjects by a grading system.

Results: : There was an age-related increase in the grade of pinguecula among both the DM group (r=0.52, p<0.0001) and the Control group (r=0.51, p<0.0001). The grade and prevalence of pinguecula were higher in the DM group than in the Control group for pinguecula of the nasal conjunctiva (grade: p<0.0001 and prevalence: 55.0% vs. 40.0%, p=0.0072) and the temporal conjunctiva (grade: p<0.0001, and prevalence: 54.4% vs. 40.0%, p=0.0100). Multivariate logistic regression analysis revealed that age and diabetes were associated with an increased prevalence of nasal or temporal pinguecula (all p<0.05). Diabetes mellitus was independently associated with the severity of pinguecula (nasal: odds ratio [OR] = 1.19; temporal: OR = 1.22) after adjustment for age.

Conclusions: : This is the first assessment of the relationship between pinguecula and diabetes mellitus. Our results suggest that diabetes mellitus may be a factor associated with the development of pinguecula.

Keywords: conjunctiva • diabetes 

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