April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Ocular Surface Morbidity in Eyes with Senile Sunken Upper Eyelids
Author Affiliations & Notes
  • Lingyi Liang
    Zhongshan Ophthalmic Center, Guangzhou, China
  • Hosam Sheha
    Ophthalmology, Ocular Surface Center, Miami, Florida
  • Scheffer C. Tseng
    Ocular Surface Center, Ocular Surface Res & Educ Fndtn, Miami, Florida
  • Footnotes
    Commercial Relationships  Lingyi Liang, None; Hosam Sheha, None; Scheffer C. Tseng, None
  • Footnotes
    Support  This study is supported by a grant for young scientist from State Key Laboratory of Ophthalmology 2010Q03 and an unrestricted grant from Ocular Surface Research and Education Foundation, Miami, FL.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 1959. doi:
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      Lingyi Liang, Hosam Sheha, Scheffer C. Tseng; Ocular Surface Morbidity in Eyes with Senile Sunken Upper Eyelids. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1959.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To report ocular surface findings in eyes with senile sunken upper eyelids.

Methods: : A study group of 34 eyes of 34 patients with sunken upper eyelids was compared to a control group of 26 age- and gender-matched patients without sunken upper eyelids. Ocular surface deficits were measured by symptoms, eyelid blinking and closure, Bell’s phenomenon, apposition of lids and puncta to the globe, conjunctiva inflammation and chalasis, corneal epithelial breakdown by fluorescein staining, and the fluorescein clearance test.

Results: : Ocular irritation or pain was less common but tearing and mucous build up were more common in the study group than the control group, and tended to be worse in the morning. Incomplete blinking, incomplete closure, abnormal Bell’s phenomenon, lid/punctum ectropion and delayed tear clearance were more frequently detected in the study group than the control group, and were more evident in severe eyes. Incomplete blinking was significantly correlated with incomplete closure while abnormal Bell’s phenomenon was significantly correlated with early morning symptoms. Conjunctival Chalasis was less common in the study group than the control group. Corneal epithelial breakdown was more common in the study group than the control group, and more severe in severe eyes.

Conclusions: : Sunken upper eyelids are associated with ocular surface morbidity characterized by corneal epithelial breakdown because of an array of ocular surface deficits leading to exposure and desiccation not only during the day but also in the night. Recognition of this potential risk factor will help understand pathogenesis and formulate effective therapies in complex ocular surface diseases.

Keywords: aging • cornea: clinical science • eyelid 

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