April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
A Retrospective Study to Assess the Process of the Diagnosis and Treatment of Ocular Surface Diseases
Author Affiliations & Notes
  • Jai G. Parekh
    Ophthalmology, The New York Eye & Ear Infirmary, NY, New York, New York
  • David R. Hardten
    Ophthalmology, Minnesota Eye Consultants, Minneapolis, Minnesota
  • Mark Milner
    Ophthalmology, Yale University School of Medicine, New Haven, Connecticut
  • Neda Shamie
    Ophthalmology, University of Southern California--Doheny Eye Institute, Los Angeles, California
  • Darrell White
    Ophthalmology, Skyvision Centers, West Lake, Ohio
  • Michael Schiewe
    Research & Development, Inspire Pharmaceuticals, Durham, North Carolina
  • Footnotes
    Commercial Relationships  Jai G. Parekh, Inspire Pharmaceuticals (F, C, R); David R. Hardten, Inspire Pharmaceuticals (F, C, R); Mark Milner, Inspire Pharmaceuticals (F, C, R); Neda Shamie, Inspire Pharmaceuticals (F, C, R); Darrell White, Inspire Pharmaceuticals (F, C, R); Michael Schiewe, Inspire Pharmaceuticals (E)
  • Footnotes
    Support  Inspire Pharmaceuticals
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 1969. doi:
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      Jai G. Parekh, David R. Hardten, Mark Milner, Neda Shamie, Darrell White, Michael Schiewe; A Retrospective Study to Assess the Process of the Diagnosis and Treatment of Ocular Surface Diseases. Invest. Ophthalmol. Vis. Sci. 2011;52(14):1969.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : This retrospective study was designed to evaluate the assessments used to diagnose Ocular Surface Disease patients and capture the severity levels of the patient’s signs and symptoms as well as the treatments that were prescribed.

Methods: : This was a retrospective, multi-center, clinical study utilizing a chart review on consecutive patients initially diagnosed with OSD. A data collection form was used to capture a primary and any secondary diagnosis of conjunctivitis, blepharitis or dry eye. The presence of any symptoms and their severity was collected along with the tests and assessments utilized to evaluate any signs of ocular surface disease.

Results: : A total of 1,157 patient charts were reviewed in the study at 52 centers in the United States over an eight week period. Dry eye was the most common general diagnosis (35%), followed by blepharitis (30%) and a mixed diagnosis of dry eye and blepharitis (29%). The remaining 6% were composed of patients diagnosed with conjunctivitis or other forms of OSD. Across the patient populations, ocular dryness and ocular burning or pain were the most common symptoms, and meibomian gland plugging was the most common sign. Corneal staining and meibomian gland expression were the most common assessments performed. Artificial tears and mechanical therapy (lid hygiene and warm compresses) were frequently recommended treatments, with pharmaceutical therapy also being commonly prescribed.

Conclusions: : This retrospective study highlights the frequent occurrence of dry eye and blepharitis as the leading diagnoses among ocular surface disease patients. Additionally, there was a large overlap of patients with a diagnosis of both dry eye and blepharitis.

Keywords: cornea: tears/tear film/dry eye • anterior segment • inflammation 

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