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Mingguang He, Zhi Lin, Yingfeng Zheng, Nathan G. Congdon; Heritability Of Peripheral Refraction: The Guangzhou Twin Eye Study. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2314.
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© ARVO (1962-2015); The Authors (2016-present)
To estimate the heritability of peripheral refraction in Chinese children and adolescents.
We examined 72 monozygotic (MZ) twins and 48 dizygotic (DZ) twins aged 8 to 20 years from a population-based twin registry. Temporal and nasal peripheral refraction, each 40 degrees from the visual axis, as well as axial refraction, were measured using a Shin-Nippon NVision-K5001 auto-refractor. Relative peripheral refractive error (RPRE) was defined as the peripheral refraction minus the axial refraction. Heritability was assessed by structural equation modeling after adjustment for age and sex.
The mean and standard deviation of temporal refraction (T40), nasal refraction (N40), RPRE-T40, RPRE-N40 and T40-N40 asymmetry were -0.27±2.0 D, 0.36±2.19 D, 1.18±1.39 D, 1.80±1.69 D and -0.62±1.58 D, respectively. The intra-class correlations for T40 refraction, N40 refraction, RPRE-T40, RPRE-N40 and T40-N40 asymmetry were 0.87, 0.83, 0.65, 0.74 and 0.58 for MZ pairs, and 0.49, 0.42, 0.30, 0.41 and 0.32 for DZ pairs, respectively. A model with additive genetic and unique environmental effects was the most parsimonious, and thewith heritability values beingwere estimated as 0.84, 0.76, 0.63, 0.70, 0.55 for the above-mentioned peripheral refractive parameters, respectively.
Additive genetic effects appear to explain most of the variance in peripheral refraction, as well as relative peripheral refraction, when adjusting for the effects of axial refraction.
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