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Amanda K. Shows, James W. Davis, Stacey Elliott, Howard A. Ketelson; Performance of a Dual Polymer Lubricant Eye Drop Containing Hydroxypropyl Guar. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2356.
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The bulk, extensional and interfacial rheological properties of a polymer may have an important influence on its retention in the eye. This work reports on the rheological properties of a dual polymer system (DPS) of an exploratory lubricant eye drop formulation containing the demulcents Polyethylene Glycol (PEG) and Polypropylene Glycol (PPG).
Physical properties were characterized using a bulk and interfacial rheometer (ARG2 and TA2000ex, double concentric cone and a platinum double wall ring) that measured the steady state flow (viscosity vs. shear rate) and oscillation (tan(Δ) vs stress(μNm) and tan(Δ) vs frequency(Hz)) of the eye drops. The extensional properties were performed with a CaBER modified with a video monitor (3mm plate with Aspect Ratio of 4). The extensional properties were characterized with a Polymer Filament Break-up Time (PFBT) measured in seconds.
The DPS formulation displayed higher viscosities from the steady state flow curves compared to the individual polymers alone. For example the DPS has a viscosity of 35cPs vs the individual polymers alone of 15cPs and 6cPs respectively at 10sec-1 (p<0.05). The DPS displayed a more viscoelastic profile compared to the individual polymers alone at higher stress levels: 30.5 vs 47.3 and below detection limit respectively at 100.0μNm. The PFBT for the DPS was significantly (p<0.05) different to the individual polymers alone: 0.25 sec vs 0.15 sec and 0.01 sec, respectively.
A novel DPS for use as a lubricant eye drop containing the demulcents PPG and PEG was characterized and showed improved bulk, extensional and interfacial rheological characteristics compared to HPG alone. These improvements may impact the long term substantivity of the polymers on the cornea to improve the on-eye performance and surface protection of lubricant eye drops.
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