April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Temporal and Nasal Retinal Blood flow Velocity Differences Detected by the Retinal Function Imager (RFI)
Author Affiliations & Notes
  • Kaare Christian
    Optical Imaging Ltd, Rehovot, Israel
  • Zvia Burgansky-Eliash
    Ophthalmology, The Edith Wolfson Medical Center, Holon, Israel
  • Hila Barsh
    Optical Imaging Ltd, Rehovot, Israel
  • Darin A. Nelson
    Optical Imaging Ltd, Rehovot, Israel
  • Amiram Grinvald
    Neurobiology, Weizmann Institute of Science, Rehovot, Israel
  • Anat Lowenstein
    Ophthalmology, Sourasky Medical Center, Tel-aviv, Israel
  • Adiel Barak
    Ophthalmology, Sourasky Medical Center, Tel-aviv, Israel
  • Footnotes
    Commercial Relationships  Kaare Christian, Optical Imaging, Ltd (E); Zvia Burgansky-Eliash, Optical Imaging, Ltd (E); Hila Barsh, Optical Imaging, Ltd (E); Darin A. Nelson, Optical Imaging, Ltd (E); Amiram Grinvald, Optical Imaging, Ltd (I, P); Anat Lowenstein, None; Adiel Barak, None
  • Footnotes
    Support  Optical Imaging, Ltd
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2134. doi:
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      Kaare Christian, Zvia Burgansky-Eliash, Hila Barsh, Darin A. Nelson, Amiram Grinvald, Anat Lowenstein, Adiel Barak; Temporal and Nasal Retinal Blood flow Velocity Differences Detected by the Retinal Function Imager (RFI). Invest. Ophthalmol. Vis. Sci. 2011;52(14):2134.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To study regional differences in retinal blood flow velocity in different areas of the macula in healthy subjects and patients with diabetes mellitus. We used the Retinal Function Imager (RFI, Optical Imaging Ltd., Rehovot, Israel), a new, non-invasive diagnostic approach for measuring blood flow velocity.

Methods: : Fifty one eyes of 31 healthy subjects and twenty three eyes of 14 patients with early DM without any signs of retinopathy were enrolled to this study. The RFI was used to image the macula using 20 degrees area analyzing blood flow velocity in multiple vascular segments simultaneously. The macular scans were divided into halves vertically and horizontally and the average velocity of segments in each hemi-retina was computed. Differences in sectorial average velocities were assessed by Students' t-test analysis.

Results: : Arterial velocity in the nasal hemi-retina was higher compared to the temporal region in the healthy group (4.38 vs 3.88 mm/sec, p=0.007). A similar difference was evident in the DM group (5.07 vs 3.94 mm/sec for nasal and temporal regions, respectively, p=0.003). However, venous velocity that was higher in the nasal region in healthy subjects (3.07 vs 2.80 mm/sec, p=0.01) did not differ regionally in veins of DM patients. Dividing the data attitudinally to superior and inferior halves did not show any differences in both groups.

Conclusions: : In both groups, a higher velocity was found in nasal arteries compared to arteries in the temporal half of the macula. This regional difference can be a result of more proximal location manifesting in higher pressure and velocity. The same phenomenon was found in the veins of the healthy group but not in the diabetic group, which may reflect the higher inter-subject variability in the diabetic group related to differences in duration of the diabetic disease. Information about regional differences in velocity, as shown here, might serve as an additional diagnostic tool especially when local retinal disease exists.

Keywords: blood supply • imaging/image analysis: clinical • macula/fovea 

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