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Wenqiu Wang, Fenghua Wang, Xiaodong Sun; Visual Functional and Morphology Change in Young Patients with Idiopathic Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2157.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the functional and morphology change of the retina with idiopathic choroidal neovascularization (ICNV) in young adults.
In this retrospectively study, 34 patients with subfoveal or juxtafoveal ICNV had been admitted into the Shanghai First People’s Hospital of SJTU from January 2009 to July 2010. The functional changes were evaluated using the best-corrected visual acuity (BCVA) and the microperimetry in the macular area. The morphology changes were evaluated using optical coherence tomography (OCT), the color fundus photography and the fluorescein angiography.
18 patients with juxtafoveal and 16 subfoveal CNV were investigated. The mean logarithm of the minimum angle of resolution (LogMAR) best corrected visual acuity (BCVA) was 0.39. The mean central retinal thickness (CRT) was 334 µm. The mean sensitivity (MS)was 11.8 dB. In the subfoveal group, there is a strong correlation between CRT and BCVA (r=-0.675, F=2.167, P=0.006, P <0.05); as well as that between CRT and MS (r=-0.681, F=22.91, P=0.005, P <0.05), In the juxtafoveal CNV group, the correlation of CRT and BCVA is not significant (r=-0.071, F=1.018, P=0.786, P >0.05); neither is the correlation of CRT and MS (r=-0.142, F=36.54, P=0.586, P >0.05). Fixation stability correlated positively with sensitivity in the central 2° diameter area (r= 0.380, F=3.213, P=0.032, P <0.05) and the duration of symptoms(r=0.401, F=7.933, P=0.023, P <0.05).
ICNV was associated with reduced total MS, unstable fixation and eccentric fixation. These findings emphasized functional change in ICNV is beyond the BCVA and regular morphology change, which provided additional information of functional evaluation in clinical practice.
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