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Barbara A. Blodi, Amitha Domalpally, Christina Kruse, Michael Ip, Ingrid U. Scott, Neal L. Oden, Paul VanVeldhuisen, SCORE Study Investigator Group; Reading Center OCT Evaluation of Partial Thickness Macular Holes in the Standard Care vs. COrticosteroid for Retinal Vein Occlusion (SCORE) Study. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2167.
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© ARVO (1962-2015); The Authors (2016-present)
To compare quantitative and qualitative optical coherence tomography (OCT) data and visual acuity (VA) data in SCORE Study participants who did versus did not develop a partial thickness macular hole.
The SCORE Study consisted of two multicenter trials comparing the safety and efficacy of intravitreal triamcinolone acetonide injections vs. standard care in participants with macular edema secondary to central (CRVO) or branch retinal vein occlusion (BRVO). Participants had Stratus OCT scans every four months for up to 3 years. We compared the OCT and VA data of SCORE Study participants with and without macular holes.
In the SCORE Study, 25 of 682 participants (13/271 or 5% with CRVO and 12/411 or 3% with BRVO) developed a partial thickness macular hole (PTMH) on OCT. No participants developed a full thickness hole. At baseline, the mean center point thickness measured with OCT was 663µ among participants who developed PTMH and 564µ among participants who did not develop a PTMH. At baseline, cysts (small, medium and large) in the central subfield were present in all participants who developed a PTMH, compared to 600/682 (88%) who did not develop a PTMH; serous subretinal fluid was present in 15/25 (60%) and 221/682 (32%) and epiretinal membrane (ERM) was found in 4/25 (16%) and 81/682 (12%), respectively. Participants who developed a PTMH had a mean VA score of 50 letters at baseline. At the time of PTMH diagnosis, mean center point thickness was 99µ and mean VA score was 48 letters. Of the 25 participants, 20 (80%) had cysts (small cysts only) in the central subfield, 1 (4%) had serous subretinal fluid and 23 (92%) had an ERM. With a mean follow up of 27 months from baseline, the mean VA score at the last visit remained at 48 letters.
In the SCORE Study, participants who developed a PTMH on OCT were found to have ERM, loss of medium and large cysts and resolution of serous subretinal fluid. The VA score remained stable before and after the development of the partial thickness macular hole. No participant developed a full thickness hole during the study.
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