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Yasushi Ikuno, Yoshiaki Yasuno, Kohji Nishida; Choroidal Thickness Mapping in Normal Healthy Subjects. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2185.
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High-penetration optical coherence tomography (HP-OCT) with a long-wavelength light source (1060 nm) allows us to visualize the deep choroid far beneath the retinal pigment epithelium (RPE). The utility of volumetric analysis which is provided by custom made software is evaluated.
Five eyes from healthy volunteers were included. Cube scan (6×6mm containing 512×255 A-scans)was performed using prototype HP-OCT (Swept source, 50;000 A-scans per second). We traced the RPE and chorio-scleral interface manually on every 4 slice from 255 B-scans (total 32 slices) and the data was analyzed by custom- made software providing the total choroidal volume and the choroidal thickness (CT) of the nine macular sectors as defined by ETDRS (Figure).
The mean age was 42.0 +/- 3.5 years old, and the mean total choroidal thickness 394 +/- 77 µm, and the total choroidal volume 8.3 +/- 2.2 mm3. The mean CT within 1mm circle was 394 micrometers. The mean CT within inner 3mm circle was 363 µm (nasal), 390 µm (superior), 391µm (temporal), and 396µm (inferior). Similarly the mean CT within 6mm outer circle was 327 µm (nasal), 391 µm (superior), 385µm (temporal), and 398µm (inferior). One-way ANOVA has suggested the nasal part was significantly thinner compared to other 3 quadrants both in inner and outer circles (P<0.05).
The volumetric analysis will be useful to obtain more 3-dimentional information of the choroid in normal eyes.
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