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Xinyuan Zhang, Mark C. Gillies, Xiaoqing Zhu; The Correlation Study of Macular Autofluorescence and Macular Pigment in Cystoids Macular Edema. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2214.
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To discuss the relationship between macular fundus autofluorecence and the density of macular pigment in the eyes with cystoid macular edema (CME), furthermore to provide the valuable parameters for patients followup.
In the retrospective case series study, 24 eyes (18 cases) with diabetic macular edema, central vein occlusion and branch vein occlusion were included in the study from July 2009 to July 2010. 24 age and sex-matched normal eyes were as the control eyes. CME was studied by color fundus photography, fluorescent angiography (FFA) and optical coherence tomography (OCT). Autoflorescence was recorded by Heidelberg retinal angiography 2 (HRA2)system Fluorescein angiography(FA) model. Macular pigment was evaluated using HRA2 IF (infrared) and FA model. The density of macular pigment was graded into three categories: those without foveal macular pigment, those with partial macular pigment and those with mormal amount macular pigment. Eyes from the age-matched subjects were used as the control eyes. Monte Carlo exact test to test the correlation of the density of macular pigment and the fundus autofluorecence, liner by liner associate test to interpret the liner trend of the two variables. Morphology and distribution of macular autofluorece, the density and distribution of macular pigment were used as the main outcome measures.
All the eyes with CME had petaloid-shaped autofluorecence in the macular area (100%). No autofluorecence was found in the control eyes (0). The density of the macular pigment varied from without macular pigment (22 eyes, 91.7%) to partial macular pigment (2 eyes, 8.3%) accordingly in the eyes with CEM. However, all the normal eyes present normal amount macular pigment (100%). Macular autofluorecence presents minus correlation with the macular pigment in the study.
The present of macular autofluorecence minus correlates the density of macular pigment. Macular autofluorecence can be used to follow up parameter for patients with CME.
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