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Jeeyun Ahn, Se Joon Woo, Kyu Hyung Park; Decreased Amyloid Beta Antigen And Antibody Levels In Age-related Macular Degeneration. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2339.
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To compare amyloid β (Aβ) antigen and antibody levels in the peripheral blood and vitreous fluid of age-related macular degeneration (AMD) patients and normal control groups.
The antigen and antibody levels of Aβ (Aβ1-42 and Aβ1-40) were analyzed after age adjustment in the sera of 321 AMD patients and 377 normal controls. Vitreous Aβ antigen and antibody titers were analyzed in the vitreous fluid of 13 AMD patients and 17 normal controls. Aβ antigen and antibody analysis was performed using enzyme-linked immunosorbent assay (ELISA).
Aβ antibody and antigen levels were decreased in AMD patient serum as well as vitreous fluid. The mean Aβ1-40 antigen titer was 0.30±0.09 and 0.31±0.08 in AMD and control sera, respectively (P = 0.014). The mean Aβ1-42 antigen titer was 0.28±0.07 and 0.29±0.06 in the sera of AMD and control cases, respectively (P = 0.008).The mean anti-Aβ1-40 antibody titer was 0.29±0.06 and 0.32±0.05 in AMD and control sera, respectively (P < 0.0001). The mean anti-Aβ1-42 antibody titer was 0.29±0.06 and 0.31±0.06 in the sera of AMD and control cases, respectively (P < 0.0001). Vitreous Aβ1-40 antigen titer was 0.039±0.003 and 0.046±0.003 in AMD and control cases, respectively (P < 0.001). Vitreous Aβ1-42 antigen titer was 0.045±0.003 and 0.046±0.002 in AMD and control cases, respectively (P = 0.191). Vitreous anti-Aβ1-40 antibody titer was 0.20±0.02 and 0.25±0.02 in AMD and control cases, respectively (P < 0.001). Vitreous anti-Aβ1-42 antibody titer was 0.22±0.02 and 0.25±0.01 in AMD and control cases, respectively (P < 0.001).
Anti-Aβ antigen and antibody levels were decreased in the sera and vitreous fluid of AMD patients compared to a normal control group. The possible role of Aβ in the pathogenesis of AMD is suggested.
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