April 2011
Volume 52, Issue 14
ARVO Annual Meeting Abstract  |   April 2011
Evaluation Of A Transgenic Mouse Model Of Multiple Sclerosis With Non Invasive Methods
Author Affiliations & Notes
  • Di Ding
    University of Miami, Miami, Florida
  • Mabel E. Algeciras
    Ophthalmology, University of Miami/Bascom Palmer, Miami, Florida
  • Tsung-Han Chou
    Bascom Palmer Eye Inst, University of Miami, Miller Sch of Med, Miami, Florida
  • Jianhua Wang
    Ophthalmology, Bascom Palmer Eye Inst Lib, Miami, Florida
  • Kyle R. Padgett
    Department of Radiology,
    University of Miami, Miami, Florida
  • Vittorio Porciatti
    University of Miami, Miami, Florida
  • Sanjoy K. Bhattacharya
    Bascom Palmer Eye Institute, University of Miami Miller Sch of Med, Miami, Florida
  • Footnotes
    Commercial Relationships  Di Ding, None; Mabel E. Algeciras, None; Tsung-Han Chou, None; Jianhua Wang, None; Kyle R. Padgett, None; Vittorio Porciatti, None; Sanjoy K. Bhattacharya, None
  • Footnotes
    Support  a career award (SKB) and unrestricted funds from Research to Prevent Blindness and NIH grants EY019077 and P30-EY14801.
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2368. doi:
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      Di Ding, Mabel E. Algeciras, Tsung-Han Chou, Jianhua Wang, Kyle R. Padgett, Vittorio Porciatti, Sanjoy K. Bhattacharya; Evaluation Of A Transgenic Mouse Model Of Multiple Sclerosis With Non Invasive Methods. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2368.

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      © ARVO (1962-2015); The Authors (2016-present)

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Purpose: : To evaluate the ND4 transgenic mouse model of multiple sclerosis using non-invasive methods.

Methods: : Assessment of neurological/behavioral abnormalities, Pattern electroretinogram (PERG), Magnetic resonance imaging (MRI), Optic coherence tomography (OCT), and endpoint histological analysis. We utilized ND4 and control mice (n= 20 each). Animals were used adhering to ARVO statement for utilization of animals in vision research.

Results: : In ND4 mice we found that PERG abnormalities preceded detection of neurologic/gait abnormalities. Longitudinal PERG recordings demonstrated that the functional deficits in vision correlated with disability score (measure of neurological/behavioral abnormalities). MRI demonstrated subtle structural changes that progressed over time in correlation with behavioral abnormalities.

Conclusions: : The ND4 mouse model has been evaluated using well defined parameters of non-invasive methods (PERG, MRI and OCT), enabling objective identification of functional and structural deficits and their correlation with neurologic/gait abnormality.

Keywords: electroretinography: non-clinical • neuro-ophthalmology: optic nerve • autoimmune disease 

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