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Di Ding, Mabel E. Algeciras, Tsung-Han Chou, Jianhua Wang, Kyle R. Padgett, Vittorio Porciatti, Sanjoy K. Bhattacharya; Evaluation Of A Transgenic Mouse Model Of Multiple Sclerosis With Non Invasive Methods. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2368.
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© ARVO (1962-2015); The Authors (2016-present)
To evaluate the ND4 transgenic mouse model of multiple sclerosis using non-invasive methods.
Assessment of neurological/behavioral abnormalities, Pattern electroretinogram (PERG), Magnetic resonance imaging (MRI), Optic coherence tomography (OCT), and endpoint histological analysis. We utilized ND4 and control mice (n= 20 each). Animals were used adhering to ARVO statement for utilization of animals in vision research.
In ND4 mice we found that PERG abnormalities preceded detection of neurologic/gait abnormalities. Longitudinal PERG recordings demonstrated that the functional deficits in vision correlated with disability score (measure of neurological/behavioral abnormalities). MRI demonstrated subtle structural changes that progressed over time in correlation with behavioral abnormalities.
The ND4 mouse model has been evaluated using well defined parameters of non-invasive methods (PERG, MRI and OCT), enabling objective identification of functional and structural deficits and their correlation with neurologic/gait abnormality.
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