April 2011
Volume 52, Issue 14
Free
ARVO Annual Meeting Abstract  |   April 2011
Retinoblastoma: Classification and Histopathologic Features of Enucleated Globes from 2004-2010 at Children’s Memorial Hospital
Author Affiliations & Notes
  • Vincent C. Fan
    Ophthalmology, McGaw Medical Center of Northwestern University, Chicago, Illinois
  • Evan Olson
    Ophthalmology, McGaw Medical Center of Northwestern University, Chicago, Illinois
  • Grace T. Wu
    Ophthalmology, McGaw Medical Center of Northwestern University, Chicago, Illinois
  • Paul Bryar
    Ophthalmology, McGaw Medical Center of Northwestern University, Chicago, Illinois
  • Footnotes
    Commercial Relationships  Vincent C. Fan, None; Evan Olson, None; Grace T. Wu, None; Paul Bryar, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science April 2011, Vol.52, 2467. doi:
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      Vincent C. Fan, Evan Olson, Grace T. Wu, Paul Bryar; Retinoblastoma: Classification and Histopathologic Features of Enucleated Globes from 2004-2010 at Children’s Memorial Hospital. Invest. Ophthalmol. Vis. Sci. 2011;52(14):2467.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To classify and report all cases of enucleated eyes for retinoblastoma at Children’s Memorial Hospital over the last 6 years and to categorize histopathologic characteristics.

Methods: : Retrospective review of charts and histopathology slides. Individual masked clinical and histopathologic data from all enucleated retinoablstoma eyes at Children’s Memorial Hospital, Division of Ophthalmology, Chicago, IL were reviewed. The following histopathologic high-risk factors were quantified: optic nerve invasion, choroidal invasion, and anterior chamber involvement. Additionally, genetics studies, if done, survival rate, and mean age of enucleation are reported.

Results: : 23 eyes of 22 patients were reviewed. We classified optic nerve involvement as: no invasion=65% (n=15); pre-laminar invasion=13% (n=3); laminar Invasion=9% (n=2); post-laminar invasion=13% (n=3); and surgical margin involvement=0% (n=0). 30% (n=7) of the subject eyes had choroidal invasion of any amount and 30% (n=7) had anterior chamber involvement. We also reviewed the cytogenetics of our subjects’ tumor: germline mutations=9% (n=2); non-germline=61% (n=14); Indeterminate=4% (n=1); no genetic studies were done=17% (n=4); and pending=9% (n=2). Survival rate was 100% at the time of last known follow-up. The mean age at the time of enucleation was 24.4 months.

Conclusions: : We describe the clinical, histopathologic and cytogenetic characteristics of enucleated eyes for retinoblastoma. Approximately 30% of the eyes had at least one of the following: optic nerve invasion, choroidal invasion, anterior chamber involvement.

Keywords: retinoblastoma • clinical (human) or epidemiologic studies: outcomes/complications • pathology: human 
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