March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
A Comparative Study Between Crosslinked Sodium Hyaluronate (healaflow Glaucoma Implant) And High Molecular Weight Sodium Hyaluronate (healon 5) As Subconjunctival Spacers Injected Into Failed Filtration Blebs During Needling With MMC
Author Affiliations & Notes
  • Beatrice Foscarini
    Jules Gonin Eye Hospital, Lausanne, Switzerland
  • Ciara Bergin
    Jules Gonin Eye Hospital, Lausanne, Switzerland
  • Eamon Sharkawi
    Jules Gonin Eye Hospital, Lausanne, Switzerland
  • Footnotes
    Commercial Relationships  Beatrice Foscarini, None; Ciara Bergin, None; Eamon Sharkawi, None
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2506. doi:https://doi.org/
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      Beatrice Foscarini, Ciara Bergin, Eamon Sharkawi; A Comparative Study Between Crosslinked Sodium Hyaluronate (healaflow Glaucoma Implant) And High Molecular Weight Sodium Hyaluronate (healon 5) As Subconjunctival Spacers Injected Into Failed Filtration Blebs During Needling With MMC. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2506. doi: https://doi.org/.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To compare the efficacy and safety of a slowly resorbable glaucoma implant, Healaflow (HF) and Healon 5 (H5) as spacers injected into failing filtration blebs at the time of bleb needlings, augmented with MMC

Methods: : Eighty-four glaucoma patients with filtration bleb failure following glaucoma surgery (deep sclerectomy/ trabeculectomy) underwent bleb needling using either HF (n=44) or H5 (n=40) as an intrableb viscoelastic spacer. All needlings were augmented by MMC and performed in the operating room, by a single surgeon. The choice between HF and H5 was randomised. Postoperative data for IOP, number of glaucoma medications (GMs), antimetabolite injections (AMIs), bleb morphology and all complications were recorded at day 1 (D1), weeks 1 (W1), 4 (W4), month 6 (M6) and last visit. Success was defined as IOP≤21mmHg and 20% reduction in IOP from baseline

Results: : Age was comparable between groups (HF vs H5; 66 vs 72 years; p=0.13*). There were no differences in mean postoperative IOP or GMs at any time point between groups (mean IOP = HF vs H5; prior to needling=19.8mmHg vs 18.7mmHg, p=0.48*; D1=10.4mmHg vs 10.2mmHg, p=0.85*; W1=12.3mmHg vs 13.8mmHg, p=0.33*; W4=15.7mmHg vs 15.1mmHg, p=0.69*; M6=14.3mmHg vs 13.8mmHg, p=0.69*. Mean GMs= HF vs H5; prior to needling=1.7 vs 1.7, p=0.96*; M6=0.9 vs 1.1, p=0.66*). Success rates were comparable between HF and H5 groups (74% vs 71%). Requirements for AMIs were similar between groups; post filtration surgery and prior to needling (mean AMIs 1.54 vs 1.65 p=0.82*) and within the first six months following needling ( 0.77 vs 0.65 p=0.70*). Complication rates were infrequent in both groups (9%, HF; 3%, H5)* two-sample t-test

Conclusions: : The early to mid-term success rates of needlings using intrableb spacers were high. However there were no differences observed between the use of crosslinked and high molecular weight sodium hyaluronate

Keywords: intraocular pressure 
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