March 2012
Volume 53, Issue 14
Free
ARVO Annual Meeting Abstract  |   March 2012
Pinpoint Identification of Filtration Opening on the Scleral Flap Margins Created by Trabeculectomy
Author Affiliations & Notes
  • Hidenobu Tanihara
    Department of Ophthalmology & Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
  • Toshihiro Inoue
    Department of Ophthalmology & Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
  • Takahiro Kawaji
    Department of Ophthalmology & Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
  • Riyo Matsumura
    Department of Ophthalmology & Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
  • Utako Kuroda
    Department of Ophthalmology & Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
  • Kei-Ichi Nakashima
    Department of Ophthalmology & Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
  • Footnotes
    Commercial Relationships  Hidenobu Tanihara, None; Toshihiro Inoue, None; Takahiro Kawaji, None; Riyo Matsumura, None; Utako Kuroda, None; Kei-Ichi Nakashima, None
  • Footnotes
    Support  Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Tokyo, Japan, and from the Ministry of Health, Labor and Welfare, Tokyo, Japan.
Investigative Ophthalmology & Visual Science March 2012, Vol.53, 2515. doi:
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      Hidenobu Tanihara, Toshihiro Inoue, Takahiro Kawaji, Riyo Matsumura, Utako Kuroda, Kei-Ichi Nakashima; Pinpoint Identification of Filtration Opening on the Scleral Flap Margins Created by Trabeculectomy. Invest. Ophthalmol. Vis. Sci. 2012;53(14):2515.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose: : To elucidate potential of three-dimensional optical coherence tomography (3D AS-OCT) for pinpoint identification of filtration openings from the scleral flap margins into the subcojunctival space.

Methods: : The included were 151 glaucomatous eyes that underwent trabeculectomy. With the use of 3D AS-OCT and newly developed software for rotation and tilting the obtained OCT images, filtration opening was identified based upon our criteria; simultaneously identified pit signs in the fluid-filled cavity in both horizontal and vertical scans, corresponding to scleral flap margin in C-scan image. Also, by using newly developed software, we analyzed total 3D images of the bleb based upon reflectivity for classifying internal structures into 4 parts, fluid-filled (blank) cavity and spaces with low, middle and high reflectivity.

Results: : In 17 (11%) of 151 eyes after trabeculectomy, neither fluid-filled cavity nor bleb wall with low reflectivity was found in entire operation fields (designated as type N, no functional bleb). In 126 (93%) of the remaining 134 eyes with potential functional blebs, pinpoint identification of filtration openings was enabled (type F, bleb with "filtration" opening) with the use of 3D AS-OCT and our newly developed software. The reasons for non-detectable filtration opening in the 8 eyes were too elevated bleb with high reflectivity causing shadow effects and resultant obscured (or no) scleral images (type H, "high" bleb) in 3 eyes, and sponge-like loose connective tissues embedded in the whole internal bleb space (type S, "sponge-like" bleb) in 5 eyes. In 97 (77%) of the 126 eyes with detectable filtration openings, only one filtration opening was noted (type F1). In the remaining 29 eyes (23%), two or more filtration openings were found (type F2). The mean intraocular pressures (IOPs) (± standard deviation) were 13.4 ± 6.5 mmHg, 15.0 ± 4.9 mmHg, 11.4 ± 3.5 mmHg, 16.2 ± 5.1 mmHg and 18.3 ± 3.8 mmHg, respectively, in types F1, F2, S, N, H. Also, bleb walls in eyes with types N and H showed higher reflectivity than other types.

Conclusions: : Three-dimensional AS-OCT with our newly developed software enables us to exactly identify filtration opening from the scleral flap margin in most cases after trabeculectomy, suggesting a potential role for the determination of therapeutic plan for the management of glaucoma after trabeculectomy.

Keywords: imaging/image analysis: clinical • wound healing 
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